ERCC excision repair 6 like, spindle assembly checkpoint helicase

ERCC excision repair 6 like, spindle assembly checkpoint helicase is a protein that in humans is encoded by the ERCC6L gene. [4]

ERCC6L
Identifiers
AliasesERCC6L, PICH, RAD26L, excision repair cross-complementation group 6 like, ERCC excision repair 6 like, spindle assembly checkpoint helicase
External IDsOMIM: 300687 MGI: 2654144 HomoloGene: 44945 GeneCards: ERCC6L
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq13.1Start72,204,657 bp[1]
End72,239,027 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

54821

236930

Ensembl

ENSG00000186871

ENSMUSG00000051220

UniProt

Q2NKX8

Q8BHK9

RefSeq (mRNA)

NM_017669
NM_001009954

NM_146235

RefSeq (protein)

NP_060139
NP_001009954

NP_666347

Location (UCSC)Chr X: 72.2 – 72.24 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis.

References

  1. GRCh38: Ensembl release 89: ENSG00000186871 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Entrez Gene: ERCC excision repair 6 like, spindle assembly checkpoint helicase". Retrieved 2017-07-29.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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