Edestin

Edestin, (also known as Edistin[1]) is a highly-digestible, hexameric legumin protein,[2][3] and a seed storage protein,[4] with a molecular weight of 50,000.[5] Edestin is a globular protein (biologically active) as opposed to fibrous protein (structural). Though the human body can manufacture globular proteins from any protein source, it is much more efficient for the body to make globulins from locally digestible globular proteins.

Edestin has the unique ability to stimulate the manufacturing process of antibodies against invasive agents[6] and contains a low aggravatory phosphor content (kidney ailments, etc.).[7]

Globular proteins found in edestin (and in Alpha 1 globulins, Alpha 2 globulins, Beta globulins and Gamma globulins) are long peptide-chains, precursors for biological proteins essential for life. Edestin is similar to serum globulin (blood plasma), and the biologically active protein of edestin is metabolized in the human body and capable of biosynthesizing:[8][9]

  • hormones (which regulate all the body processes),
  • haemoglobin (which transports oxygen, carbon dioxide, and nitric oxide),
  • enzymes (which catalyze and control biochemical reactions),
  • antibodies (immunoglobulins which fend off invading bacteria, viruses, and other pathogens, as well as toxins or antigens as they enter the body).

Edestin can also be broken down to edestan.[10]


Hemp seed

Commercial hemp seeds (for human consumption) contain an average 30-35% protein, of which 60-80% is edestin (the remainder being albumin).[11] A particular strain of Korean hemp, Cheungsam, because it contains 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, has been suggested for utilization as "a superior antioxidative nutrient".[8]

References
  1. Möller G, Fernandez C (1978). "Immunological tolerance to the thymus-independent antigen dextran can be abrogated by thymus-dependent dextran conjugates: evidence against clonal deletion as the mechanism of tolerance induction". Scandinavian Journal of Immunology. 8 (1): 29–37. doi:10.1111/j.1365-3083.1978.tb00493.x. PMID 309173.
  2. Patel S, Cudney R, McPherson A (January 1994). "Crystallographic characterization and molecular symmetry of edestin, a legumin from hemp". J. Mol. Biol. 235 (1): 361–3. doi:10.1016/S0022-2836(05)80040-3. PMID 8289257.
  3. Chuan-He Tang (November 15, 2006). "Physicochemical and functional properties of hemp (Cannabis sativa L.) protein isolate". J Agric Food Chem. 54 (23): 8945–8950. doi:10.1021/jf0619176. PMID 17090145.
  4. Teresa Docimo (September 24, 2014). "Molecular characterization of edestin gene family in Cannabis sativa L". Plant Physiology and Biochemistry. 84: 142–148. doi:10.1016/j.plaphy.2014.09.011. PMID 25280223.
  5. https://www.britannica.com/science/protein/Proteins-of-the-blood-serum#ref593830
  6. Nixdorff KK, Schlecht S, Rüde E, Westphal O (1975). "Immunological responses to Salmonella R antigens. The bacterial cell and the protein edestin as carriers for R oligosaccharide determinants". Immunology. 29 (1): 87–102. PMC 1445874. PMID 49297.
  7. Steele TH, DeLuca HF (1976). "Influence of dietary phosphorus on renal phosphate reabsorption in the parathyroidectomized rat". The Journal of Clinical Investigation. 57 (4): 867–74. doi:10.1172/JCI108363. PMC 436730. PMID 947958.
  8. Kim, Jum-Ji (2011), "Isolation and Characterization of Edestin from Cheungsam Hempseed", Journal of Applied Biological Chemistry, 54 (2): 84–88, doi:10.3839/jabc.2011.015
  9. Tombs MP (1960). "A haemoglobin-binding beta-globulin in human serum". Nature. 186 (4730): 1055–6. doi:10.1038/1861055b0. PMID 13838734.
  10. Kenneth Bailey (January 29, 1942). "The denaturation of edestin by acid: T. B. Osborne's edestan". Biochemical Journal. 36 (1–2): 140–154. doi:10.1042/bj0360140. PMC 1265671. PMID 16747476.
  11. Galasso, Incoronata (2016), "Variability in Seed Traits in a Collection of Cannabis sativa L. Genotypes", Frontiers in Plant Science, 7: 688, doi:10.3389/fpls.2016.00688, PMC 4873519, PMID 27242881


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