Edmund McMillen

McMillen and programmer Tommy Refenes established Team Meat, an independent game production company, with the intent that they would never utilize a third-party publisher.[16] Their first game, Super Meat Boy, was released on October 20, 2010 on the Xbox 360 via Xbox Live Arcade,[17] and on Valve's digital distribution system Steam on November 30, 2010.[18] A release was planned for the Nintendo Wii, but was canceled. According to Kotaku, problems arose due to the file size limitations of the Wii's WiiWare Channel.[19] A retail version of the game was released on April 5, 2011.[20] Due to Sony's initial lack of interest in the game, Team Meat entered into contractual obligations that prohibit the game from being released for the Sony PlayStation 3.[21] McMillen and Refenes responded to the success of Super Meat Boy and the impossibility of a sequel in a brief statement that read, "We feel like we did it...the 1st time."[22] McMillen and Refenes' development of Super Meat Boy was featured in the film Indie Game: The Movie.

A sequel titled Super Meat Boy Forever has been confirmed for a 2018 release though in a 2017 interview with Eurogamer, Refenes revealed that McMillen was no longer a part of Team Meat and would likely not play a role in the development of the game's sequel.[23] McMillen later confirmed this in a blog post.[24][25]

The Binding of Isaac is an indie roguelike video game designed by Edmund McMillen and Florian Himsl, initially released in 2011 for Microsoft Windows; the game was later ported for OS X, and Linux operating systems. The game's title and plot are inspired by the Biblical story of the Binding of Isaac. In the game, Isaac's mother receives a message from God demanding the life of her son as proof of her faith, and Isaac flees into the monster-filled basement of their home where he must fight to survive. Players control Isaac or one of six other unlockable characters through a procedurally generated dungeon in a roguelike manner, fashioned after those of The Legend of Zelda, defeating monsters in real-time combat while collecting items and power-ups to defeat bosses and eventually Isaac's mother.

The game was the result of a week-long game jam between McMillen and Himsl to develop a The Legend of Zelda-inspired roguelike that allowed McMillen to showcase his feelings about both positive and negative aspects of religion that he had come to discover from conflicts between his Catholic and born again Christian family members while growing up. McMillen had considered the title a risk but one he could take after the financial success of Super Meat Boy, and released it without much fanfare to Steam in September 2011, not expecting many sales. The game soon gained popularity partially as a result of various Let's Play videos showcasing the title. McMillen and Himsl released an expansion "Wrath of the Lamb" in May 2012, but were limited from further expansion due to limitations with the Flash platform. They had started working with Nintendo in 2012 to release a 3DS version, but Nintendo later backed out of the deal, citing controversy over the game's religious themes.

Developer Nicalis worked with McMillen in 2014 to complete a remake of the game, The Binding of Isaac: Rebirth, bringing additional features that McMillen had planned that exceeded Flash's limitation, as well as to improve the game's graphics and enable ports for other systems beyond personal computers, including PlayStation 4 and Vita, Xbox One, Wii U, Nintendo 3DS, and the Nintendo Switch.

The End Is Nigh is a platforming adventure video game developed by Edmund McMillen and Tyler Glaiel. The game was released on July 12, 2017 on Microsoft Windows via Steam. Ports of the game were released on August 15, 2017 on macOS and on December 12, 2017 for Linux and Nintendo Switch, with a port for the PlayStation 4 and PlayStation Vita in development. The game has been described as a spiritual successor to McMillen's Super Meat Boy.