FAT4

FAT4
Identifiers
Aliases	FAT4, CDHF14, CDHR11, FAT-J, FATJ, NBLA00548, VMLDS2, HKLLS2, FAT atypical cadherin 4
External IDs	OMIM: 612411 MGI: 3045256 HomoloGene: 14377 GeneCards: FAT4
Gene location (Human)
Chr.	Chromosome 4 (human)[1]
End	125,492,932 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	39,011,985 bp[2]
Gene ontology
Molecular function	• GO:0001948 protein binding; • calcium ion binding;
Cellular component	• integral component of membrane; • apical part of cell; • membrane; • intracellular; • cell membrane; • extracellular exosome;
Biological process	• cerebral cortex development; • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; • homophilic cell adhesion via plasma membrane adhesion molecules; • neurogenesis; • heart morphogenesis; • regulation of metanephric nephron tubule epithelial cell differentiation; • kidney development; • plasma membrane organization; • digestive tract development; • inner ear receptor stereocilium organization; • ossification involved in bone maturation; • Hippo signaling pathway; • branching involved in ureteric bud morphogenesis; • cell adhesion; • nephron development; • fibroblast growth factor receptor signaling pathway; • Notch signaling pathway; • condensed mesenchymal cell proliferation; • cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	79633
	329628
	ENSG00000196159
	ENSMUSG00000046743
	Q6V0I7
	Q2PZL6
	NM_001291285; NM_001291303; NM_024582
	NM_183221
	NP_001278214; NP_001278232; NP_078858; NP_001278214.1; NP_001278232.1
	NP_899044
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene.[5][6]

FAT4 is associated with the Hippo signaling pathway.[7]

Clinical significance

Mutations in FAT4 are associated to Hennekam syndrome.[8]

References

GRCh38: Ensembl release 89: ENSG00000196159 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000046743 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: FAT tumor suppressor homolog 4 (Drosophila)".
Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". J. Mol. Biol. 337 (2): 307–17. doi:10.1016/j.jmb.2004.01.026. PMID 15003449.
Qi C, Zhu YT, Hu L, Zhu YJ (February 2009). "Identification of Fat4 as a candidate tumor suppressor gene in breast cancers". Int. J. Cancer. 124 (4): 793–8. doi:10.1002/ijc.23775. PMC 2667156. PMID 19048595.
Alders, M; Al-Gazali, L; Cordeiro, I; Dallapiccola, B; Garavelli, L; Tuysuz, B; Salehi, F; Haagmans, M. A.; Mook, O. R.; Majoie, C. B.; Mannens, M. M.; Hennekam, R. C. (2014). "Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome". Human Genetics. 133 (9): 1161–1167. doi:10.1007/s00439-014-1456-y. PMID 24913602. S2CID 14414158.

Katoh Y, Katoh M (2006). "Comparative integromics on FAT1, FAT2, FAT3 and FAT4". Int. J. Mol. Med. 18 (3): 523–8. doi:10.3892/ijmm.18.3.523. PMID 16865240.
Caporaso N, Gu F, Chatterjee N, et al. (2009). Reitsma PH (ed.). "Genome-wide and candidate gene association study of cigarette smoking behaviors". PLOS ONE. 4 (2): e4653. doi:10.1371/journal.pone.0004653. PMC 2644817. PMID 19247474.
Liu Y, Blackwood DH, Caesar S, et al. (2010). "Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder". Molecular Psychiatry. 16 (1): 2–4. doi:10.1038/mp.2009.107. PMC 3883627. PMID 20351715.
Need AC, Attix DK, McEvoy JM, et al. (2009). "A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB". Hum. Mol. Genet. 18 (23): 4650–61. doi:10.1093/hmg/ddp413. PMC 2773267. PMID 19734545.
Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Ballif BA, Villén J, Beausoleil SA, et al. (2004). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Johnson AD, Kavousi M, Smith AV, et al. (2009). "Genome-wide association meta-analysis for total serum bilirubin levels". Hum. Mol. Genet. 18 (14): 2700–10. doi:10.1093/hmg/ddp202. PMC 2701336. PMID 19414484.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196159 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046743 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FAT tumor suppressor homolog 4 (Drosophila)".

[pmid15003449-6] Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". J. Mol. Biol. 337 (2): 307–17. doi:10.1016/j.jmb.2004.01.026. PMID 15003449.

[pmid19048595-7] Qi C, Zhu YT, Hu L, Zhu YJ (February 2009). "Identification of Fat4 as a candidate tumor suppressor gene in breast cancers". Int. J. Cancer. 124 (4): 793–8. doi:10.1002/ijc.23775. PMC 2667156. PMID 19048595.

[8] Alders, M; Al-Gazali, L; Cordeiro, I; Dallapiccola, B; Garavelli, L; Tuysuz, B; Salehi, F; Haagmans, M. A.; Mook, O. R.; Majoie, C. B.; Mannens, M. M.; Hennekam, R. C. (2014). "Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome". Human Genetics. 133 (9): 1161–1167. doi:10.1007/s00439-014-1456-y. PMID 24913602. S2CID 14414158.

Signaling pathway: Hippo signaling pathway
Receptor	FAT4
Adaptor protein	NF2 FRMD6 SAV1 MOBKL1A MOBKL1B
Kinase	MST1 LATS1 LATS2 STK3
Transcription factor	YAP1 TAZ
Other/unknown	RASSF1

FAT4

Clinical significance

References

Further reading