FAT4

Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene.[5][6]

FAT4
Identifiers
AliasesFAT4, CDHF14, CDHR11, FAT-J, FATJ, NBLA00548, VMLDS2, HKLLS2, FAT atypical cadherin 4
External IDsOMIM: 612411 MGI: 3045256 HomoloGene: 14377 GeneCards: FAT4
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q28.1Start125,316,399 bp[1]
End125,492,932 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

79633

329628

Ensembl

ENSG00000196159

ENSMUSG00000046743

UniProt

Q6V0I7

Q2PZL6

RefSeq (mRNA)

NM_001291285
NM_001291303
NM_024582

NM_183221

RefSeq (protein)

NP_001278214
NP_001278232
NP_078858
NP_001278214.1
NP_001278232.1

NP_899044

Location (UCSC)Chr 4: 125.32 – 125.49 MbChr 3: 38.89 – 39.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FAT4 is associated with the Hippo signaling pathway.[7]

Clinical significance

Mutations in FAT4 are associated to Hennekam syndrome.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000196159 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000046743 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: FAT tumor suppressor homolog 4 (Drosophila)".
  6. Höng JC, Ivanov NV, Hodor P, Xia M, Wei N, Blevins R, Gerhold D, Borodovsky M, Liu Y (March 2004). "Identification of new human cadherin genes using a combination of protein motif search and gene finding methods". J. Mol. Biol. 337 (2): 307–17. doi:10.1016/j.jmb.2004.01.026. PMID 15003449.
  7. Qi C, Zhu YT, Hu L, Zhu YJ (February 2009). "Identification of Fat4 as a candidate tumor suppressor gene in breast cancers". Int. J. Cancer. 124 (4): 793–8. doi:10.1002/ijc.23775. PMC 2667156. PMID 19048595.
  8. Alders, M; Al-Gazali, L; Cordeiro, I; Dallapiccola, B; Garavelli, L; Tuysuz, B; Salehi, F; Haagmans, M. A.; Mook, O. R.; Majoie, C. B.; Mannens, M. M.; Hennekam, R. C. (2014). "Hennekam syndrome can be caused by FAT4 mutations and be allelic to Van Maldergem syndrome". Human Genetics. 133 (9): 1161–1167. doi:10.1007/s00439-014-1456-y. PMID 24913602. S2CID 14414158.

Further reading


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