FCN1

Ficolin-1, and also commonly termed M-ficolin is a protein that in humans is encoded by the FCN1 gene.[5][6][7]

FCN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFCN1, FCNM, ficolin 1
External IDsOMIM: 601252 MGI: 1341158 HomoloGene: 1518 GeneCards: FCN1
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q34.3Start134,903,232 bp[1]
End134,917,912 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2219

14134

Ensembl

ENSG00000085265

ENSMUSG00000026835

UniProt

O00602

O70497

RefSeq (mRNA)

NM_002003

NM_010190

RefSeq (protein)

NP_001994

NP_034320

Location (UCSC)Chr 9: 134.9 – 134.92 MbChr 2: 28.08 – 28.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proteins of the ficolin family consist of a leader peptide, a short N-terminal segment, followed by a collagen-like domain, and a C-terminal fibrinogen-like domain. The name of ficolin was derived from the latter two domains. The collagen-like and the fibrinogen-like domains are also found in other proteins such as tenascins, while the former is also found in complement protein C1q and collectins, which include mannose-binding lectin and lung surfactant proteins. Ficolins selectively recognize acetylated compounds. M-ficolin encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. Several SNPs have been described in the FCN1 gene with impact on serum concentrations of M-ficolin and the ligand binding ability. M-ficolin levels reflect disease activity and predict remission in early rheumatoid arthritis.

References

  1. GRCh38: Ensembl release 89: ENSG00000085265 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026835 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lu J, Tay PN, Kon OL, Reid KB (Mar 1996). "Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9". Biochem J. 313 (2): 473–8. doi:10.1042/bj3130473. PMC 1216931. PMID 8573080.
  6. Endo Y, Sato Y, Matsushita M, Fujita T (Feb 1997). "Cloning and characterization of the human lectin P35 gene and its related gene". Genomics. 36 (3): 515–21. doi:10.1006/geno.1996.0497. PMID 8884275.
  7. "Entrez Gene: FCN1 ficolin (collagen/fibrinogen domain containing) 1".

Further reading

Arthritis Rheum. 2013 Dec;65(12):3045-50. doi: 10.1002/art.38179. M-ficolin levels reflect disease activity and predict remission in early rheumatoid arthritis. Ammitzbøll CG1, Thiel S, Jensenius JC, Ellingsen T, Hørslev-Petersen K, Hetland ML, Junker P, Krogh NS, Østergaard M, Stengaard-Pedersen K.


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