FKBP5

FK506 binding protein 5, also known as FKBP5, is a protein which in humans is encoded by the FKBP5 gene.[5]

FKBP5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFKBP5, AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10, FK506 binding protein 5, FKBP prolyl isomerase 5
External IDsOMIM: 602623 MGI: 104670 HomoloGene: 3038 GeneCards: FKBP5
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.31Start35,573,585 bp[1]
End35,728,583 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2289

14229

Ensembl

ENSG00000096060

ENSMUSG00000024222

UniProt

Q13451

Q64378

RefSeq (mRNA)

NM_004117
NM_001145775
NM_001145776
NM_001145777

NM_010220

RefSeq (protein)

NP_001139247
NP_001139248
NP_001139249
NP_004108

NP_034350

Location (UCSC)Chr 6: 35.57 – 35.73 MbChr 17: 28.4 – 28.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants tacrolimus (FK506) and sirolimus (rapamycin). It is thought to mediate calcineurin inhibition. It also interacts functionally with mature corticoid receptor hetero-complexes (i.e. progesterone-, glucocorticoid-, mineralocorticoid-receptor complexes) along with the 90 kDa heat shock protein and P23 protein.

Clinical significance

The FKBP5 gene has been found to have multiple polyadenylation sites[5] and is statistically associated with a higher rate of depressive disorders.[6]

Interactions

FKBP5 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1.[7]

See also

  • FKBP4 - a functional antagonist to FKBP5 at corticoid receptors

References

  1. GRCh38: Ensembl release 89: ENSG00000096060 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000024222 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: FKBP5 FK506 binding protein 5".
  6. Binder EB, Salyakina D, Lichtner P, Wochnik GM, Ising M, Pütz B, Papiol S, Seaman S, Lucae S, Kohli MA, Nickel T, Künzel HE, Fuchs B, Majer M, Pfennig A, Kern N, Brunner J, Modell S, Baghai T, Deiml T, Zill P, Bondy B, Rupprecht R, Messer T, Köhnlein O, Dabitz H, Brückl T, Müller N, Pfister H, Lieb R, Mueller JC, Lõhmussaar E, Strom TM, Bettecken T, Meitinger T, Uhr M, Rein T, Holsboer F, Muller-Myhsok B (December 2004). "Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment". Nat. Genet. 36 (12): 1319–25. doi:10.1038/ng1479. PMID 15565110. S2CID 21914515.
  7. Nair SC, Rimerman RA, Toran EJ, Chen S, Prapapanich V, Butts RN, Smith DF (Feb 1997). "Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor". Mol. Cell. Biol. 17 (2): 594–603. doi:10.1128/MCB.17.2.594. PMC 231784. PMID 9001212.

Further reading

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