FKBPL

FK506-binding protein like, also known as FKBPL, is a protein that in humans is encoded by the FKBPL gene.[4]

FKBPL
Identifiers
AliasesFKBPL, DIR1, NG7, WISP39, FKBP4, FK506 binding protein like, FKBP prolyl isomerase like
External IDsOMIM: 617076 MGI: 1932127 HomoloGene: 10529 GeneCards: FKBPL
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p21.32Start32,128,707 bp[1]
End32,130,288 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

63943

56299

Ensembl

ENSG00000204315
ENSG00000230907
ENSG00000224200
ENSG00000223666

ENSMUSG00000033739

UniProt

Q9UIM3

O35450

RefSeq (mRNA)

NM_022110

NM_019873

RefSeq (protein)

NP_071393
NP_071393.2

NP_063926

Location (UCSC)Chr 6: 32.13 – 32.13 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

FKBPL has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle.[5]

FKBPL is involved in cellular response to stress. It was first isolated in 1999 and was initially named DIR1.[6] It was later reclassified because of its homology to the FKBP family of proteins and was renamed FKBP-like (FKBPL). A separate study that found it to be involved in the stabilisation of newly synthesised p21 termed it Wisp39.[7]

It is known to interact with Hsp90, glucocorticoid receptor and dynamitin and may play a role in signalling, like other FKBPs.[8]

FKBPL has also been shown to influence estrogen receptor signalling and can have a determinant effect on response to the breast cancer drug tamoxifen.[9]

References
  1. ENSG00000230907, ENSG00000224200, ENSG00000223666 GRCh38: Ensembl release 89: ENSG00000204315, ENSG00000230907, ENSG00000224200, ENSG00000223666 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Robson TA, Lohrer H, Bailie JR, Hirst DG, Joiner MC, Arrand JE (February 1997). "Gene regulation by low-dose ionizing radiation in a normal human lung epithelial cell line". Biochem. Soc. Trans. 25 (1): 335–42. doi:10.1042/bst0250335. PMID 9056895.
  5. "Entrez Gene: FKBPL".
  6. Robson T, Joiner MC, Wilson GD, McCullough W, Price ME, Logan I, Jones H, McKeown SR, Hirst DG (November 1999). "A novel human stress response-related gene with a potential role in induced radioresistance". Radiat. Res. 152 (5): 451–61. Bibcode:1999RadR..152..451R. doi:10.2307/3580140. JSTOR 3580140. PMID 10521921.
  7. Jascur T, Brickner H, Salles-Passador I, Barbier V, El Khissiin A, Smith B, Fotedar R, Fotedar A (January 2005). "Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein". Mol. Cell. 17 (2): 237–49. doi:10.1016/j.molcel.2004.11.049. PMID 15664193.
  8. McKeen HD, McAlpine K, Valentine A, Quinn DJ, McClelland K, Byrne C, O'Rourke M, Young S, Scott CJ, McCarthy HO, Hirst DG, Robson T (July 2008). "A novel FK506-like binding protein (FKBPL) interacts with the glucocorticoid receptor and regulates steroid receptor signalling". Endocrinology. 149 (11): 5724–34. doi:10.1210/en.2008-0168. PMID 18669603.
  9. McKeen HD, Byrne C, Jithesh PV, Donley C, Valentine A, Yakkundi A, O'Rourke M, Swanton C, McCarthy HO, Hirst DG, Robson T (February 2010). "FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy". Cancer Res. 70 (3): 1090–100. doi:10.1158/0008-5472.CAN-09-2515. PMID 20103631.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.