FLRT1

FLRT1
Identifiers
Aliases	FLRT1, SPG68, fibronectin leucine rich transmembrane protein 1
External IDs	OMIM: 604806 MGI: 3026647 HomoloGene: 40864 GeneCards: FLRT1
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	64,119,173 bp[1]
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)[2]
End	7,105,729 bp[2]
Gene ontology
Molecular function	• protein binding, bridging; • fibroblast growth factor receptor binding; • protein kinase inhibitor activity;
Cellular component	• cytoplasm; • integral component of membrane; • cell projection; • endoplasmic reticulum membrane; • membrane; • intercellular junction; • focal adhesion; • integral component of plasma membrane; • neuronal cell body membrane; • extracellular region; • cell junction; • endoplasmic reticulum; • perinuclear region of cytoplasm; • neuron projection terminus; • cytoplasmic vesicle membrane; • cytoplasmic vesicle; • cell membrane; • extracellular; • extracellular matrix;
Biological process	• negative regulation of protein kinase activity; • cytokine-mediated signaling pathway; • dendrite development; • neuron projection extension; • multicellular organism development; • cell adhesion; • negative regulation of JAK-STAT cascade; • positive regulation of synapse assembly; • fibroblast growth factor receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23769
	396184
	ENSG00000126500
	ENSMUSG00000047787
	Q9NZU1
	Q6RKD8
	NM_013280
	NM_201411
	NP_037412
	NP_958813
	Wikidata
View/Edit Human	View/Edit Mouse

Fibronectin leucine rich transmembrane protein 1 is a protein that in humans is encoded by the FLRT1 gene. [5]

Function

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in the kidney and brain.

References

GRCh38: Ensembl release 89: ENSG00000126500 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000047787 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Fibronectin leucine rich transmembrane protein 1". Retrieved 2017-05-30.

FLRT1

Function

References

Further reading