Flavokavain B
Flavokavain B is a flavokavain found in the kava plant.[1] In 2010 a paper was published identifying it as a glutathione-depleting hepatotoxin.[2]
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| Names | |
|---|---|
| IUPAC name
(E)-1-(2-Hydroxy-4,6-dimethoxy-phenyl)-3-phenyl-propenone | |
| Other names
2'-hydroxy-4',6'-dimethoxychalcone Flavokawain B | |
| Identifiers | |
3D model (JSmol) |
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| 2059845 | |
PubChem CID |
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| Properties | |
| C17H16O4 | |
| Molar mass | 284.311 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is  ?) | |
| Infobox references | |
FKB is said by enthusiasts to occur at higher concentrations in "tudei" kava strains, which are generally considered less desirable.
See also
References
- Dharmaratne, H. Ranjith W.; N. P. Dhammika Nanayakkara; Ikhlas A. Khan (February 2002). "Kavalactones from Piper methysticum, and their 13C NMR spectroscopic analyses". Phytochemistry. 59 (4): 429–33. doi:10.1016/S0031-9422(01)00443-5. PMID 11830162.
- Zhou P., Gross S., Liu J.-H., Yu B.-Y., Feng L.-L., Nolta J., Sharma V., Piwnica-Worms D., Qiu S.X 'Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-κB and MAPK signaling pathways . FASEB Journal 2010 24:12 (4722-4732)
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