GDP-4-dehydro-6-deoxy-D-mannose reductase

In enzymology, a GDP-4-dehydro-6-deoxy-D-mannose reductase (EC 1.1.1.281) is an enzyme that catalyzes the chemical reaction

GDP-6-deoxy-D-mannose + NAD(P)+ GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+
GDP-4-dehydro-6-deoxy-D-mannose reductase
Identifiers
EC number1.1.1.281
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The 3 substrates of this enzyme are GDP-6-deoxy-D-mannose, NAD+, and NADP+, whereas its 4 products are GDP-4-dehydro-6-deoxy-D-mannose, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming). Other names in common use include GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous], GDP-6-deoxy-D-lyxo-4-hexulose reductase, and Rmd. This enzyme participates in fructose and mannose metabolism.

References
    • Messner P; Graninger, M; Adam, G; Puchberger, M; Kosma, P; Zayni, S; Messner, P (2001). "Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T". J. Biol. Chem. 276 (8): 5577–83. doi:10.1074/jbc.M010027200. PMID 11096116.
    • Maki M, Jarvinen N, Rabina J, Roos C, Maaheimo H, Renkonen R (2002). "Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose". Eur. J. Biochem. 269 (2): 593–601. doi:10.1046/j.0014-2956.2001.02688.x. PMID 11856318.


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