GDP-6-deoxy-D-talose 4-dehydrogenase
In enzymology, a GDP-6-deoxy-D-talose 4-dehydrogenase (EC 1.1.1.135) is an enzyme that catalyzes the chemical reaction
- GDP-6-deoxy-D-talose + NAD(P)+ GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+
| GDP-6-deoxy-D-talose 4-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.135 | ||||||||
| CAS number | 37250-66-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are GDP-6-deoxy-D-talose, NAD+, and NADP+, whereas its 4 products are GDP-4-dehydro-6-deoxy-D-mannose, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is GDP-6-deoxy-D-talose:NAD(P)+ 4-oxidoreductase. This enzyme is also called guanosine diphospho-6-deoxy-D-talose dehydrogenase. This enzyme participates in fructose and mannose metabolism.
References
- Markovitz A (July 1964). "Biosynthesis of guanosine diphosphate D-rhamnose and guanosine diphosphate D-talomethylose from guanosine diphosphate alpha-D-mannose". The Journal of Biological Chemistry. 239: 2091–8. PMID 14209931.
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