GRB10

The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors (e.g., IGF1R and IGF2R). Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]

Mice whose paternally inherited Grb10 gene is inactivated are more aggressive while those whose maternally inherited allele is inactivated exhibit foetal overgrowth and are significantly bigger than wild-type litter-mates.[9]

GRB10 has been shown to interact with

• Abl gene,[10][11]
• BCR gene,[10]
• C-Raf,[12][13]
• c-Kit,[14]
• Insulin receptor,[11][15][16][17][18]
• Insulin-like growth factor 1 receptor,[18][19][20][21]
• MAP2K1,[13] and
• RET proto-oncogene.[22]

• GRB10+Protein at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.