Gitoformate
Gitoformate (INN, or pentaformylgitoxin, trade name Dynocard) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat).[1] Produced by Madaus, it is not available in the US, and does not seem to be available in Europe either.
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| Trade names | Dynocard |
| Other names | Gitoxin 3',3'',3''',4''',16-pentaformate |
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| ECHA InfoCard | 100.030.397  |
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| Formula | C46H64O19 |
| Molar mass | 920.999 g·mol−1 |
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Chemistry
Gitoxigenin, the aglycon
Gitoformate is a derivative of the glycoside gitoxin, with five of the six free hydroxyl groups formylated, one on the aglycon and four on the sugar.[2][3] Gitoxin, a cardiac glycoside from the woolly foxglove (Digitalis lanata), has an aglycon of the cardenolide type named gitoxigenin, which is also the aglycon of lanatoside B, another Digitalis lanata glycoside.[4]
References
- Rietbrock N, Woodcock BG, Hrazdil U (1984). "[Gitoformate and digitoxin as alternatives to kidney-dependent glycosides in the therapy of cardiac insufficiency]". Arzneimittel-Forschung. 34 (8): 915–7. PMID 6541927.
- Dei Cas L, Affatato A, Buia E, Casciarri G, Faggiano P, Giunti G, et al. (1984). "[Plasma levels of gitoxin (by RIA and rubidium-86 uptake) and systolic time after treatment with a single dose of gitoformate]". Cardiologia. 29 (5–6): 291–300. PMID 6542412.
- CID 91540 from PubChem
- Foye WO, Lemke TL, Williams DA (2008). Foye's principles of medicinal chemistry. p. 699. ISBN 978-0-7817-6879-5.
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