Marinobufagenin

Marinobufagenin
Names
	Other names Marinobufagin, Marinobufagenin
Identifiers
CAS Number	470-42-8 ;
3D model (JSmol)	Interactive image;
ChemSpider	10142870 ;
PubChem CID	11969465;
UNII	3KBT25GV2B ;
CompTox Dashboard (EPA)	DTXSID5041063 ;
	InChI InChI=1S/C24H32O5/c1-21-8-5-15(25)12-23(21,27)10-7-17-16(21)6-9-22(2)18(11-19-24(17,22)29-19)14-3-4-20(26)28-13-14/h3-4,13,15-19,25,27H,5-12H2,1-2H3/t15-,16-,17+,18+,19+,21+,22+,23-,24+/m0/s1 Key: JMNQTHQLNRILMH-OBBGIPBRSA-N ; InChI=1/C24H32O5/c1-21-8-5-15(25)12-23(21,27)10-7-17-16(21)6-9-22(2)18(11-19-24(17,22)29-19)14-3-4-20(26)28-13-14/h3-4,13,15-19,25,27H,5-12H2,1-2H3/t15-,16-,17+,18+,19+,21+,22+,23-,24+/m0/s1 Key: JMNQTHQLNRILMH-OBBGIPBRBU;
	SMILES C[C@]12CC[C@@H](C[C@]1(CCC3C2CC[C@]4([C@]35[C@H](O5)C[C@@H]4C6=COC(=O)C=C6)C)O)O;
Properties
Chemical formula	C24H32O5
Molar mass	400.515 g·mol−1
Hazards
Main hazards	Toxic
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Marinobufagenin (marinobufagin) is a cardiotonic bufadienolide steroid secreted by the toad Bufo rubescens[1] and other related species such as Bufo marinus. It is a vasoconstrictor with effects similar to digitalis.[2]

References

Cunha Filho, GA; Schwartz, CA; Resck, IS; Murta, MM; Lemos, SS; Castro, MS; Kyaw, C; Pires Jr, OR; et al. (2005). "Antimicrobial activity of the bufadienolides marinobufagin and telocinobufagin isolated as major components from skin secretion of the toad Bufo rubescens". Toxicon. 45 (6): 777–82. doi:10.1016/j.toxicon.2005.01.017. PMID 15804527.
Fedorova, OV; Talan, MI; Agalakova, NI; Lakatta, EG; Bagrov, AY (2002). "Endogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride--dependent hypertension". Circulation. 105 (9): 1122–7. doi:10.1161/hc0902.104710. PMID 11877366.

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