Gluconate 2-dehydrogenase
In enzymology, a gluconate 2-dehydrogenase (EC 1.1.1.215) is an enzyme that catalyzes the chemical reaction
- D-gluconate + NADP+ 2-dehydro-D-gluconate + NADPH + H+
| gluconate 2-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.215 | ||||||||
| CAS number | 68417-42-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are D-gluconate and NADP+, whereas its 3 products are 2-dehydro-D-gluconate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-gluconate:NADP+ oxidoreductase. Other names in common use include 2-keto-D-gluconate reductase, and 2-ketogluconate reductase.
References
- Ameyama M (1978). "Crystalline 2-ketogluconate reductase from Acetobacter ascendens, the second instance of crystalline enzyme in genus Acetobacter". Agric. Biol. Chem. 42 (11): 2057–2062. doi:10.1271/bbb1961.42.2057.
- Chiyonobu T, Shinagawa E, Adachi O, Ameyama M (1976). "Purification, crystallization and properties of 2-ketogluconate reductase from Acetobacter rancens". Agric. Biol. Chem. 40: 175–184. doi:10.1271/bbb1961.40.175.
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