HIST1H3C

Histone H3.1 is a protein that in humans is encoded by the HIST1H3C gene.[5][6][7][8]

HIST1H3C
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHIST1H3C, H3.1, H3/c, H3FC, histone cluster 1, H3c, histone cluster 1 H3 family member c
External IDsOMIM: 602812 MGI: 2448355 HomoloGene: 134495 GeneCards: HIST1H3C
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p22.2Start26,045,411 bp[1]
End26,045,821 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

8352

15077

Ensembl

ENSG00000278272

ENSMUSG00000093769

UniProt

P68431

P84228

RefSeq (mRNA)

NM_003531

NM_178216

RefSeq (protein)

NP_066298
NP_003520
NP_003525
NP_003527

Location (UCSC)Chr 6: 26.05 – 26.05 MbChr 3: 96.25 – 96.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes, and functions in the compaction of chromatin into higher order structures.

This gene is intronless, and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails, instead containing a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000278272 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000093769 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kardalinou E, Eick S, Albig W, Doenecke D (Dec 1993). "Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones". Journal of Cellular Biochemistry. 52 (4): 375–83. doi:10.1002/jcb.240520402. PMID 8227173. S2CID 42454232.
  6. Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
  7. Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  8. "Entrez Gene: HIST1H3C histone cluster 1, H3c".

Further reading


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