HOOK2

HOOK2
Identifiers
Aliases	HOOK2, HK2, hook microtubule-tethering protein 2, hook microtubule tethering protein 2
External IDs	OMIM: 607824 MGI: 2181664 HomoloGene: 8332 GeneCards: HOOK2
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	12,872,740 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	85,003,349 bp[2]
Gene ontology
Molecular function	• GO:0001948 protein binding; • identical protein binding; • microtubule binding; • dynein light intermediate chain binding;
Cellular component	• HOPS complex; • cytoplasm; • microtubule organizing center; • centrosome; • microtubules; • cytoskeleton; • FHF complex; • cytosol; • intracellular membrane-bounded organelle;
Biological process	• protein transport; • lysosome organization; • early endosome to late endosome transport; • endocytosis; • endosome organization; • endosome to lysosome transport; • cytoskeleton-dependent intracellular transport; • cytoplasmic microtubule organization;
	Sources:Amigo / QuickGO
Orthologs
	29911
	170833
	ENSG00000095066
	ENSMUSG00000052566
	Q96ED9
	Q7TMK6
	NM_001100176; NM_013312
	NM_001167991; NM_133255; NM_001363497; NM_001363498
	NP_001093646; NP_037444
NP_001161463; NP_573518; NP_001350426; NP_001350427; NP_001359286;
	NP_001359287; NP_001359288; NP_001359289; NP_001359290; NP_001359291
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Hook homolog 2 (HK2) is a protein[5] that in humans is encoded by the HOOK2 gene.[6][7]

Function

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[7]

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Xu L, Sowa ME, Chen J, et al. (2008). "An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex". Mol. Biol. Cell. 19 (12): 5059–71. doi:10.1091/mbc.E08-05-0473. PMC 2592673. PMID 18799622.
Moynihan KL, Pooley R, Miller PM, et al. (2009). "Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome". Mol. Biol. Cell. 20 (22): 4790–803. doi:10.1091/mbc.E09-07-0560. PMC 2777108. PMID 19793914.
Szebenyi G, Wigley WC, Hall B, et al. (2007). "Hook2 contributes to aggresome formation". BMC Cell Biol. 8: 19. doi:10.1186/1471-2121-8-19. PMC 1896156. PMID 17540036.
Szebenyi G, Hall B, Yu R, et al. (2007). "Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function". Traffic. 8 (1): 32–46. doi:10.1111/j.1600-0854.2006.00511.x. PMID 17140400.
Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442.

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