Invasive lobular carcinoma
Invasive lobular carcinoma is breast cancer arising from the lobules of the mammary glands.[1] It accounts for 5-10% of invasive breast cancer.[2][3]
| Invasive lobular carcinoma | |
|---|---|
 | |
| Lobules of the mammary glands. | |
| Specialty | Oncology |
Histopathologic types of breast cancer, with relative incidences and prognoses, with "invasive lobular carcinoma" at top right.
The histologic patterns include:[4][5][6]
| Type | Prevalence | Description | Image |
|---|---|---|---|
| Classical | 40% | round or ovoid cells with little cytoplasm in a single-file infiltrating pattern, sometimes concentrically giving a targetoid pattern | .jpg.webp) |
| Mixed | 40% | No dominant pattern | |
| Solid | 10% | Sheets of classical-appearing cells with little intervening stroma | |
| Alveolar | 5% | Aggregates of classical-appearing cells | |
| Tubulolobular | 5% | Cells form microtubules in >90% of tumor (smaller than in tubular carcinoma) | |
| Pleomorphic | Classical-appearing but with pleomorphic cells |
Histopathology of invasive lobular carcinoma (ILC), next to lobular carcinoma in situ (LCIS)..jpg.webp)
Invasive lobular carcinoma demonstrating a predominantly lobular growth pattern.
Lobular breast cancer. Single file cells and cell nests.
Overall, the five-year survival rate of invasive lobular carcinoma was approximately 85% in 2003.[7]
Loss of E-cadherin is common in lobular carcinoma but is also seen in other breast cancers.[8]
Treatment includes surgery and adjuvant therapy.
References
- "Breast Cancer Treatment (PDQ®)". NCI. 23 May 2014. Archived from the original on 5 July 2014. Retrieved 29 June 2014.
- Pointon KS, Cunningham DA (August 1999). "Ultrasound findings in pure invasive lobular carcinoma of the breast: comparison with matched cases of invasive ductal carcinoma of the breast". Breast. 8 (4): 188–90. doi:10.1054/brst.1999.0042. PMID 14731438.
- Boughey JC, Wagner J, Garrett BJ, et al. (March 2009). "Neoadjuvant Chemotherapy in Invasive Lobular Carcinoma May Not Improve Rates of Breast Conservation". Ann. Surg. Oncol. 16 (6): 1606–11. doi:10.1245/s10434-009-0402-z. PMC 4338983. PMID 19280264.
- Moore MM, Borossa G, Imbrie JZ, et al. (June 2000). "Association of Infiltrating Lobular Carcinoma With Positive Surgical Margins After Breast-Conservation Therapy". Ann. Surg. 231 (6): 877–82. doi:10.1097/00000658-200006000-00012. PMC 1421077. PMID 10816631.
- Spencer JT, Shutter J (March 2009). "Synchronous bilateral invasive lobular breast cancer presenting as carcinomatosis in a male". Am. J. Surg. Pathol. 33 (3): 470–4. doi:10.1097/PAS.0b013e318190d10d. PMID 19092630.
- Fletcher's diagnostic histopathology of tumors. 3rd Ed. p. 931-932.
- Arpino G, Bardou VJ, Clark GM, Elledge RM (2004). "Infiltrating lobular carcinoma of the breast: tumor characteristics and clinical outcome". Breast Cancer Res. 6 (3): R149–56. doi:10.1186/bcr767. PMC 400666. PMID 15084238.
- Varga Z, Mallon E (Oct 2009). "Histology and Immunophenotype of Invasive Lobular Breast Cancer. Daily Practice and Pitfalls" (PDF). Breast Dis. 30: 15–19. doi:10.3233/BD-2009-0278. PMID 19850991.
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