Jean-Martin Charcot

Charcot uses hypnotism to treat hysteria and other abnormal mental conditions. All materials from "Iconographie photographique de la Salpêtrière" (Jean Martin Charcot, 1878)

Charcot's primary focus was neurology. He named and was the first to describe multiple sclerosis.[2][13] Summarizing previous reports and adding his own clinical and pathological observations, Charcot called the disease sclérose en plaques. The three signs of multiple sclerosis now known as Charcot's triad 1 are nystagmus, intention tremor, and telegraphic speech, though these are not unique to MS. Charcot also observed cognition changes, describing his patients as having a "marked enfeeblement of the memory" and "conceptions that formed slowly". He was also the first to describe a disorder known as Charcot joint or Charcot arthropathy, a degeneration of joint surfaces resulting from loss of proprioception. He researched the functions of different parts of the brain and the role of arteries in cerebral hemorrhage.[2]

Charcot was among the first to describe Charcot–Marie–Tooth disease (CMT). The announcement was made simultaneously with Pierre Marie of France (his resident) and Howard Henry Tooth of England. The disease is also sometimes called peroneal muscular atrophy.[14]

Charcot's studies between 1868 and 1881 were a landmark in the understanding of Parkinson's disease.[15] Among other advances he made the distinction between rigidity, weakness and bradykinesia.[15] He also led the disease formerly named paralysis agitans (shaking palsy) to be renamed after James Parkinson.[15] He also noted apparent variations on PD, such as Parkinson's disease with hyperextension.[16] Charcot received the first European professional chair of clinical diseases for the nervous system in 1882.[17]

Charcot is best known today for his work on hypnosis and hysteria. In particular, he is best remembered for his work with his hysteria patient Louise Augustine Gleizes, who somewhat increased his fame during his lifetime; however, Marie "Blanche" Wittmann, known as the Queen of Hysterics, was his most famous hysteria patient at the time.[18][19][3] He initially believed that hysteria was a neurological disorder for which patients were pre-disposed by hereditary features of their nervous system,[8][20] but near the end of his life he concluded that hysteria was a psychological disease.[21]

Charcot first began studying hysteria after creating a special ward for non-insane females with "hystero-epilepsy". He discovered two distinct forms of hysteria among these women: minor hysteria and major hysteria.[22] His interest in hysteria and hypnotism "developed at a time when the general public was fascinated in 'animal magnetism' and 'mesmerization'",[23] which was later revealed to be a method of inducing hypnosis.[24] His study of hysteria "attract[ed] both scientific and social notoriety".[25] Bogousslavsky, Walusinski, and Veyrunes write:

Charcot and his school considered the ability to be hypnotized as a clinical feature of hysteria ... For the members of the Salpêtrière School, susceptibility to hypnotism was synonymous with disease, i.e. hysteria, although they later recognized ... that grand hypnotisme (in hysterics) should be differentiated from petit hypnotisme, which corresponded to the hypnosis of ordinary people.[23]

Charcot argued vehemently against the widespread medical and popular prejudice that hysteria was rarely found in men, presenting several cases of traumatic male hysteria.[26] He taught that due to this prejudice these "cases often went unrecognised, even by distinguished doctors"[27] and could occur in such models of masculinity as railway engineers or soldiers. Charcot's analysis, in particular his view of hysteria as an organic condition which could be caused by trauma, paved the way for understanding neurological symptoms arising from industrial-accident or war-related traumas.[28]

The Salpêtrière School's position on hypnosis was sharply criticized by Hippolyte Bernheim, another leading neurologist of the time.[23] Bernheim argued that the hypnosis and hysteria phenomena that Charcot had famously demonstrated were in fact due to suggestion. However, Charcot himself had had longstanding concerns about the use of hypnosis in treatment and about its effect on patients. He also was concerned that the sensationalism hypnosis attracted had robbed it of its scientific interest,[25] and that the quarrel with Bernheim, amplified by Charcot's pupil Georges Gilles de la Tourette, had "damaged" hypnotism.[23]

The painting "A Clinical Lesson at the Salpêtrière" by Pierre Aristide André Brouillet. This painting shows Charcot demonstrating hypnosis on a "hysterical" Salpêtrière patient, "Blanche" (Marie "Blanche" Wittmann), who is supported by Dr. Joseph Babiński (rear). Note the similarity to the illustration of opisthotonus (tetanus) on the back wall.[29]

Charcot thought of art as a crucial tool of the clinicoanatomic method. He used photos and drawings, many made by himself or his students, in his classes and conferences. He also drew outside the neurology domain, as a personal hobby. Like Duchenne, he is considered a key figure in the incorporation of photography to the study of neurological cases.[30]

Distorted views of Charcot as harsh and tyrannical have arisen from some sources that rely on a fanciful autobiographical novel by Axel Munthe, The Story of San Michele (1929). Munthe claimed to have been Charcot's assistant, but in fact, Munthe was just a medical student among hundreds of others. Munthe's most direct contact with Charcot was when Munthe helped a young female patient "escape" from a ward of the hospital and took her into his home. Charcot threatened to report this to the police, and ordered that Munthe not be allowed on the wards of the hospital again.[31]

In a 1931 letter to The New York Times Book Review, Charcot's son Jean-Baptiste Charcot, who had, himself, been a formal student of his father at the Salpêtrière, emphatically stated:

I can certify that Dr Munthe never was trained by my father"; and, further, that "[although Munthe] may have [incidentally] followed, like hundreds of others, some courses of Charcot, ...he was not trained by him and certainly never had the intimacy of which he boasts [in his recently reviewed work, Memories and Vagaries]. ...I was, myself, a student at the Salpetriere then, and can certify that he was not one of his students and that my father never knew him. Everything he says about professor Charcot is false....[32]

Bengt Jangfeldt, in his 2008 biography, Axel Munthe: The Road to San Michele, states that "Charcot is not mentioned in a single letter of Axel's out of the hundreds that have been preserved from his Paris years" (p. 96).[33]

Charcot claimed to have observed a higher prevalence of diseases with a hereditary component (notably arthritis and neurological disorders) in Jewish communities, where limited numbers combined with longterm endogamy. He also used Jewish patients as examples in some of his public lectures.[44]

When these claims were developed by neurologist Henry Meige, and others, in conjunction with the myth of the Wandering Jew, this was used as support by the apostles of French anti-Semitism, notably the journalist Edouard Drumont.[45] However, historian of science Ian Hacking cautions that Charcot's interest in Jews and his claims about them must be seen in their nuanced, ambiguous context: "notice how Charcot shared most of the presuppositions of the genetic approach to mental illness that are current today [1998].

He could not fall back on a genome project to support his scientific speculations, but he did have a closed gene pool to study, not just in that Jews were endogenous but because many Jews in his clinic were descended from relatives, even cousins, who married each other. Scientific reasoning could motivate his constant attention to Jewish family lines .... Thus a reputable scientific quest merged with a great willingness to see Jews as aberrant, troublesome, ill."[46]

However, by the very end of the 19th century, anti-Semitism in France had rapidly accentuated, due to the Dreyfus affair. "Because of this transition, it has become all too easy to read gross and manifest anti-Semitism" retrospectively into the hospital wards of one or two decades previous.[47]

Charcot's name is associated with many diseases and conditions including:[2]

• Charcot's artery (lenticulostriate artery)
• Charcot's joint (diabetic arthropathy)
• Charcot's disease (amyotrophic lateral sclerosis, the most-common subtype of motor neurone disease—also known as Lou Gehrig's disease.)
• Charcot–Marie–Tooth disease (peripheral muscular atrophy), named with Pierre Marie and Howard Henry Tooth.
• Charcot–Wilbrand syndrome (visual agnosia and loss of ability to revisualise images), named with Hermann Wilbrand.
• Charcot's intermittent hepatic fever (intermittent pain, intermittent fever, intermittent jaundice, and loss of weight)
• Charcot–Bouchard aneurysms (tiny aneurysms of the penetrating branches of middle cerebral artery in hypertensives), named with Charles-Joseph Bouchard.
• Charcot's triad of acute cholangitis (right upper quadrant pain, jaundice, and fever)
• Charcot's neurologic triad of multiple sclerosis (nystagmus, intention tremor, and dysarthria)
• Charcot–Leyden crystals due to the lysis of eosinophils in cases of allergic diseases, named with Ernst Viktor von Leyden.
• Souques–Charcot geroderma: a variant of Hutchinson–Gilford disease, named with Alexandre-Achille Souques.[48]
• Charcot–Gombault necrosis: a biliary infarct, named with Albert Gombault.[49]