Kahweol
Kahweol is a diterpenoid molecule found in the beans of Coffea arabica. It is structurally related to cafestol. It gets its name from the Arabic word "Ka-ah-wa", from which "coffee" derives. In French, it's evolved into the slang word "kawa", to designate coffee.
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(3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b-Decahydro-7-hydroxy-10b-methyl-5a,8-Methano-5aH-cyclohepta(5,6)naphtho(2,1-b)furan-7-methanol | |
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| C20H26O3 | |
| Molar mass | 314.425 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Recent research suggests that kahweol may have beneficial effects on bone by inhibiting osteoclast differentiation.[1] Another recent study confirmed that kahweol has anti-inflammatory and anti-angiogenic effects, offering a possible mechanism for the association found in epidemiological studies between consumption of unfiltered coffee and decreased risk of cancer.[2]
See also
References
- Fumimoto R, Sakai E, Yamaguchi Y, Sakamoto H, Fukuma Y, Nishishita K, Okamoto K, Tsukuba T (Mar 2012). "The Coffee Diterpene Kahweol Prevents Osteoclastogenesis via Impairment of NFATc1 Expression and Blocking of Erk Phosphorylation". J Pharmacol Sci. 118 (4): 479–86. doi:10.1254/jphs.11212FP. PMID 22447306.CS1 maint: uses authors parameter (link)
- Cárdenas C, Quesada AR, Medina MA (Aug 2011). "Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene". PLoS ONE. 6 (8): e23407. doi:10.1371/JOURNAL.PONE.0023407. PMC 3153489. PMID 21858104.CS1 maint: uses authors parameter (link)
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