LY-88329

LY-88329
Identifiers
	IUPAC name 3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-1-phenylpropan-1-one;
CAS Number	78693-86-4;
PubChem CID	10042707;
ChemSpider	4953075;
ChEMBL	ChEMBL94345;
Chemical and physical data
Formula	C22H27NO2
Molar mass	337.463 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H]1CN(CC[C@@]1(C)C2=CC(=CC=C2)O)CCC(=O)C3=CC=CC=C3;
	InChI InChI=1S/C22H27NO2/c1-17-16-23(13-11-21(25)18-7-4-3-5-8-18)14-12-22(17,2)19-9-6-10-20(24)15-19/h3-10,15,17,24H,11-14,16H2,1-2H3/t17-,22+/m0/s1; Key:IQGJBVSSFDCTAJ-HTAPYJJXSA-N;

LY-88329 is an opioid receptor ligand related to medicines such as pethidine. It has high affinity to the μ-opioid receptor, but unlike structurally related drugs such as 3-methylfentanyl and OPPPP, LY-88329 is a potent opioid antagonist. In animal studies it blocks the effects of morphine and has anorectic action.[1][2]

References

Leander JD (July 1981). "Behavioral effects of phenylpiperidine narcotic antagonists". Pharmacology, Biochemistry, and Behavior. 15 (1): 65–70. doi:10.1016/0091-3057(81)90340-3. PMID 7291232.
Shaw WN, Mitch CH, Leander JD, Zimmerman DM (April 1990). "Effect of phenylpiperidine opioid antagonists on food consumption and weight gain of the obese Zucker rat". The Journal of Pharmacology and Experimental Therapeutics. 253 (1): 85–9. PMID 2329525.

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[1] Leander JD (July 1981). "Behavioral effects of phenylpiperidine narcotic antagonists". Pharmacology, Biochemistry, and Behavior. 15 (1): 65–70. doi:10.1016/0091-3057(81)90340-3. PMID 7291232.

[2] Shaw WN, Mitch CH, Leander JD, Zimmerman DM (April 1990). "Effect of phenylpiperidine opioid antagonists on food consumption and weight gain of the obese Zucker rat". The Journal of Pharmacology and Experimental Therapeutics. 253 (1): 85–9. PMID 2329525.

LY-88329

See also

References