Leukotriene C4 hydrolase
Leukotriene-C4 hydrolase (EC 3.4.19.14, gamma-glutamyl leukotrienase) is an enzyme.[1][2][3][4] Gamma-glutamyltransferase 5 (GGT5) is a human gene which encodes an enzyme protein that belongs to this class of enzymes. This enzyme catalyses the following chemical reaction
- leukotriene C4 + H2O leukotriene D4 + L-glutamate
| Leukotriene-C4 hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.19.14 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The mouse enzyme is specific for leukotriene C4.
References
- Carter BZ, Wiseman AL, Orkiszewski R, Ballard KD, Ou CN, Lieberman MW (May 1997). "Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice". The Journal of Biological Chemistry. 272 (19): 12305–10. doi:10.1074/jbc.272.19.12305. PMID 9139674.
- Shi ZZ, Han B, Habib GM, Matzuk MM, Lieberman MW (August 2001). "Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response". Molecular and Cellular Biology. 21 (16): 5389–95. doi:10.1128/mcb.21.16.5389-5395.2001. PMC 87261. PMID 11463821.
- Han B, Luo G, Shi ZZ, Barrios R, Atwood D, Liu W, Habib GM, Sifers RN, Corry DB, Lieberman MW (August 2002). "Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo". The American Journal of Pathology. 161 (2): 481–90. doi:10.1016/s0002-9440(10)64204-6. PMC 1850737. PMID 12163373.
- Wickham S, West MB, Cook PF, Hanigan MH (July 2011). "Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes". Analytical Biochemistry. 414 (2): 208–14. doi:10.1016/j.ab.2011.03.026. PMC 3099546. PMID 21447318.
External links
- Leukotriene-C4+hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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