Limonene-1,2-diol dehydrogenase
Limonene-1,2-diol dehydrogenase (EC 1.1.1.297, NAD+-dependent limonene-1,2-diol dehydrogenase) is an enzyme with systematic name menth-8-ene-1,2-diol:NAD+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction
- menth-8-ene-1,2-diol + NAD+ 1-hydroxymenth-8-en-2-one + NADH + H+ (general reaction)
- (1) (1S,2S,4R)-menth-8-ene-1,2-diol + NAD+ (1S,4R)-1-hydroxymenth-8-en-2-one + NADH + H+
- (2) (1R,2R,4S)-menth-8-ene-1,2-diol + NAD+ (1R,4S)-1-hydroxymenth-8-en-2-one + NADH + H+
| Limonene-1,2-diol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.297 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
While the enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 can use both (1S,2S,4R)- and (1R,2R,4S)-menth-8-ene-1,2-diol as substrate, activity is higher with (1S,2S,4R)-menth-8-ene-1,2-diol as substrate.
References
- van der Werf MJ, Swarts HJ, de Bont JA (May 1999). "Rhodococcus erythropolis DCL14 contains a novel degradation pathway for limonene". Applied and Environmental Microbiology. 65 (5): 2092–102. PMC 91303. PMID 10224006.
External links
- Limonene-1,2-diol+dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)
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