Lisa Edelstein

After being dubbed a "celebutante" by The New York Times magazine during her Club Kid days,[3] Edelstein used her new-found celebrity to write, compose and star in an original musical called Positive Me[9] in response to the growing AIDS crisis of the 1980s. The play, performed at La MaMa Experimental Theatre Club in New York City, received many accolades.[3][10] After an unsuccessful stint hosting Awake on the Wild Side for MTV in 1990,[11] she appeared as a backstage make-up artist in Oliver Stone's Jim Morrison biography The Doors, followed by guest roles on several popular comedies, including Mad About You, Wings, and The Larry Sanders Show. On Sports Night, she played a sports reporter who claimed to be a former lover of Josh Charles' character whom he did not remember. On Seinfeld, she played George Costanza's sexually frustrated girlfriend in the episodes "The Masseuse" and "The Mango".

Edelstein picketed during the 2007–08 Writers Guild of America strike, which halted the production of House.

Bigger roles in TV dramas soon followed, among them the lesbian sister on ABC's Relativity (1996); a high-priced call girl turned Rob Lowe's date on The West Wing (1999); an assigned male at birth (AMAB) transgender woman on Ally McBeal (2000); and Ben Covington's (Scott Speedman) girlfriend on Felicity (2001). She also continued to land guest-star spots on such shows as ER, Frasier, Just Shoot Me!, Without a Trace, and Judging Amy, as well as small parts in the films What Women Want, Keeping the Faith, As Good as It Gets, and Daddy Day Care.

From 2004 to 2011, she portrayed her biggest and most notable role to date, Dr. Lisa Cuddy, the Dean of Medicine at Princeton-Plainsboro Teaching Hospital and frequent adversary, friend, and eventual girlfriend of title character Gregory House (Hugh Laurie) on Fox's TV series House. Edelstein has often spoken fondly of her experiences on the show and fellow cast and crew, especially her friendship and strong working relationship with Laurie.

In May 2011, Edelstein announced that she would not return for the eighth and final season of House.[12] Starting in June 2011, she joined the cast of The Good Wife where she played lawyer Celeste Serrano.[13] She guest-starred in Scandal in 2013, and later three episodes of the ABC series Castle.

She also starred as the lead role of Abby McCarthy in the Bravo series Girlfriends' Guide to Divorce, an hour-long comedy-drama loosely based on the book series by Vicki Iovine and which premiered on December 2, 2014. In 2018, Edelstein joined the cast of ABC's The Good Doctor in season two as Dr. Blaize in a recurring role. This reunited her with House creator David Shore.[14] Edelstein also plays a recurring character in The Kominsky Method, a Netflix series that debuted in November 2018.

She has lent her voice to several animated programs, including King of the Hill, American Dad!, Superman: The Animated Series (as Mercy Graves, Lex Luthor's bodyguard, a role she later reprised in several episodes of Justice League), Legend of Korra (as Kya, Tenzin's sister) and the video game adaptation of Blade Runner.

Edelstein is a supporter of Best Friends Animal Society, of which she is an Ambassador. She supports human rights organizations and is a patron of the arts. She has appeared in numerous magazines, including the September 2010 cover of H magazine.[15] She posed for PETA in an ad promoting vegetarianism, a diet she has followed for most of her life.[16]