List of artists who reached number one on the Italian Singles Chart

This is a list of recording artists who have reached number one on the singles chart in Italy since Federazione Industria Musicale Italiana (FIMI) began reporting charts on 6 January 1996.

Sfera Ebbasta scored 16 number-one songs in Italy, more than any other artist during the FIMI era.

With a total of 16 songs, Sfera Ebbasta hold the record for the most number-ones songs during the FIMI era. Madonna holds the record for a female artist, with 12.

• All acts are listed alphabetically.
• Solo artists are alphabetized by last name, Groups by group name excluding "A", "An", and "The".
• Each act's total of number-one singles is shown after their name.
• All artists who are mentioned in song credits are listed here; this includes one-time pairings of otherwise solo artists and those appearing as featured. Members of a group who reached number one are excluded, unless they hit number one as a solo artist.