MKI67IP

MKI67 FHA domain-interacting nucleolar phosphoprotein is a protein that in humans is encoded by the MKI67IP gene.[5][6]

NIFK
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNIFK, MKI67IP, Nopp34, nucleolar protein interacting with the FHA domain of MKI67
External IDsOMIM: 611970 MGI: 1915199 HomoloGene: 49862 GeneCards: NIFK
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q14.3Start121,726,945 bp[1]
End121,736,911 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

84365

67949

Ensembl

ENSG00000155438

ENSMUSG00000026377

UniProt

Q9BYG3

Q91VE6

RefSeq (mRNA)

NM_032390

NM_026472

RefSeq (protein)

NP_115766

NP_080748

Location (UCSC)Chr 2: 121.73 – 121.74 MbChr 1: 118.32 – 118.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
FHA Ki67 binding domain of hNIFK
the solution structure of the ki67fha/hnifk(226-269)3p complex
Identifiers
SymbolhNIFK_binding
PfamPF12196
InterProIPR021043

MKI67 FHA domain-interacting nucleolar phosphoprotein contains an RNA recognition motif (RRM) near to the N-terminus and a FHA Ki67 binding domain near to the C-terminus. There are two conserved sequence motifs within the FHA Ki67 binding domain: TPVCTP and LERRKS, this domain binds to the forkhead-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in cell cycle regulation.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000155438 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026377 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Takagi M, Sueishi M, Saiwaki T, Kametaka A, Yoneda Y (Jul 2001). "A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis". J Biol Chem. 276 (27): 25386–91. doi:10.1074/jbc.M102227200. PMID 11342549.
  6. "Entrez Gene: MKI67IP MKI67 (FHA domain) interacting nucleolar phosphoprotein".
  7. Byeon IJ, Li H, Song H, Gronenborn AM, Tsai MD (November 2005). "Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67". Nat. Struct. Mol. Biol. 12 (11): 987–93. doi:10.1038/nsmb1008. PMID 16244663. S2CID 5680428.

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)


This article incorporates text from the public domain Pfam and InterPro: IPR021043


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