MKI67IP

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

FHA Ki67 binding domain of hNIFK
	the solution structure of the ki67fha/hnifk(226-269)3p complex
Identifiers
Symbol	hNIFK_binding
Pfam	PF12196
InterPro	IPR021043
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

NIFK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2AFF
Identifiers
Aliases	NIFK, MKI67IP, Nopp34, nucleolar protein interacting with the FHA domain of MKI67
External IDs	OMIM: 611970 MGI: 1915199 HomoloGene: 49862 GeneCards: NIFK
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	121,736,911 bp[1]
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)[2]
End	118,333,822 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • RNA binding; • nucleic acid binding;
Cellular component	• cytoplasm; • condensed nuclear chromosome; • chromosome; • nucleolus; • cell nucleus; • nucleoplasm;
Biological process	• negative regulation of phosphatase activity; • rRNA transcription; • rRNA metabolic process; • macromolecular complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	84365
	67949
	ENSG00000155438
	ENSMUSG00000026377
	Q9BYG3
	Q91VE6
	NM_032390
	NM_026472
	NP_115766
	NP_080748
	Wikidata
View/Edit Human	View/Edit Mouse

MKI67 FHA domain-interacting nucleolar phosphoprotein is a protein that in humans is encoded by the MKI67IP gene.[5][6]

MKI67 FHA domain-interacting nucleolar phosphoprotein contains an RNA recognition motif (RRM) near to the N-terminus and a FHA Ki67 binding domain near to the C-terminus. There are two conserved sequence motifs within the FHA Ki67 binding domain: TPVCTP and LERRKS, this domain binds to the forkhead-associated domain of human Ki67. High-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in cell cycle regulation.[7]

References

GRCh38: Ensembl release 89: ENSG00000155438 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026377 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Takagi M, Sueishi M, Saiwaki T, Kametaka A, Yoneda Y (Jul 2001). "A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis". J Biol Chem. 276 (27): 25386–91. doi:10.1074/jbc.M102227200. PMID 11342549.
"Entrez Gene: MKI67IP MKI67 (FHA domain) interacting nucleolar phosphoprotein".
Byeon IJ, Li H, Song H, Gronenborn AM, Tsai MD (November 2005). "Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67". Nat. Struct. Mol. Biol. 12 (11): 987–93. doi:10.1038/nsmb1008. PMID 16244663. S2CID 5680428.

PDBe-KB provides an overview of all the structure information available in the PDB for Human MKI67 FHA domain-interacting nucleolar phosphoprotein (MKI67IP)

This article incorporates text from the public domain Pfam and InterPro: IPR021043

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