Major vault protein

Major vault protein is a protein that in humans is encoded by the MVP gene.[5][6] 78 copies of the protein assemble into the large compartments called vaults, illustrated and discussed in the article on Vault (organelle).

MVP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMVP, LRP, VAULT1, major vault protein
External IDsOMIM: 605088 MGI: 1925638 HomoloGene: 3752 GeneCards: MVP
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16p11.2Start29,820,394 bp[1]
End29,848,039 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9961

78388

Ensembl

ENSG00000013364

ENSMUSG00000030681

UniProt

Q14764

Q9EQK5

RefSeq (mRNA)

NM_017458
NM_001293204
NM_001293205
NM_005115

NM_080638

RefSeq (protein)

NP_001280133
NP_001280134
NP_005106
NP_059447
NP_001280134.1

NP_542369

Location (UCSC)Chr 16: 29.82 – 29.85 MbChr 7: 126.99 – 127.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes the major vault protein which is a lung infection resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.[6]

Interactions

Major vault protein has been shown to interact with Estrogen receptor alpha,[7] PTEN[8] and PARP4.[9][10]

References

  1. GRCh38: Ensembl release 89: ENSG00000013364 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030681 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Scheffer GL, Wijngaard PL, Flens MJ, Izquierdo MA, Slovak ML, Pinedo HM, Meijer CJ, Clevers HC, Scheper RJ (Jun 1995). "The drug resistance-related protein LRP is the human major vault protein". Nature Medicine. 1 (6): 578–82. doi:10.1038/nm0695-578. hdl:20.500.11755/c49e6086-ede3-4b91-ac6e-4ab9158c6cac. PMID 7585126. S2CID 29771830.
  6. "Entrez Gene: MVP major vault protein".
  7. Abbondanza C, Rossi V, Roscigno A, Gallo L, Belsito A, Piluso G, Medici N, Nigro V, Molinari AM, Moncharmont B, Puca GA (Jun 1998). "Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell". The Journal of Cell Biology. 141 (6): 1301–10. doi:10.1083/jcb.141.6.1301. PMC 2132791. PMID 9628887.
  8. Yu Z, Fotouhi-Ardakani N, Wu L, Maoui M, Wang S, Banville D, Shen SH (Oct 2002). "PTEN associates with the vault particles in HeLa cells". The Journal of Biological Chemistry. 277 (43): 40247–52. doi:10.1074/jbc.M207608200. PMID 12177006.
  9. van Zon A, Mossink MH, Schoester M, Scheffer GL, Scheper RJ, Sonneveld P, Wiemer EA (Mar 2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochemical and Biophysical Research Communications. 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. PMID 11855821.
  10. Kickhoefer VA, Siva AC, Kedersha NL, Inman EM, Ruland C, Streuli M, Rome LH (Sep 1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". The Journal of Cell Biology. 146 (5): 917–28. doi:10.1083/jcb.146.5.917. PMC 2169495. PMID 10477748.

Further reading


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