SNRPB2

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.[4][5]

SNRPB2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSNRPB2, Msl1, U2B, small nuclear ribonucleoprotein polypeptide B2
External IDsOMIM: 603520 MGI: 104805 HomoloGene: 37728 GeneCards: SNRPB2
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20p12.1Start16,729,961 bp[1]
End16,742,564 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6629

20639

Ensembl

ENSG00000125870

ENSMUSG00000008333

UniProt

P08579

Q9CQI7

RefSeq (mRNA)

NM_198220
NM_003092

NM_021335

RefSeq (protein)

NP_003083
NP_937863

NP_067310

Location (UCSC)Chr 20: 16.73 – 16.74 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000125870 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Habets WJ, Sillekens PT, Hoet MH, Schalken JA, Roebroek AJ, Leunissen JA, van de Ven WJ, van Venrooij WJ (May 1987). "Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen". Proc Natl Acad Sci U S A. 84 (8): 2421–5. doi:10.1073/pnas.84.8.2421. PMC 304663. PMID 2951739.
  5. "Entrez Gene: SNRPB2 small nuclear ribonucleoprotein polypeptide B".

Further reading

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