Mepivacaine
Mepivacaine /mɛˈpɪvəkeɪn/ is a local anesthetic[1] of the amide type. Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine) and is marketed under various trade names including Carbocaine and Polocaine.
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AHFS/Drugs.com | Consumer Drug Information |
MedlinePlus | a603026 |
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ECHA InfoCard | 100.002.313 ![]() |
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Formula | C15H22N2O |
Molar mass | 246.354 g·mol−1 |
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Mepivacaine became available in the United States in the 1960s.
Mepivacaine is used in any infiltration and regional anesthesia.
It is supplied as the hydrochloride salt of the racemate, [2] which consists of R(-)-mepivacaine and S(+)-mepivacaine in equal proportions. These two enantiomers have markedly different pharmacokinetic properties. [3]
References
- Porto GG, Vasconcelos BC, Gomes AC, Albert D (January 2007). "Evaluation of lidocaine and mepivacaine for inferior third molar surgery" (PDF). Med Oral Patol Oral Cir Bucal. 12 (1): E60–4. PMID 17195831.
- Burm AG, Cohen IM, van Kleef JW, Vletter AA, Olieman W, Groen K (January 1997). "Pharmacokinetics of the enantiomers of mepivacaine after intravenous administration of the racemate in volunteers". Anesth. Analg. 84 (1): 85–9. doi:10.1097/00000539-199701000-00016. PMID 8989005. S2CID 22363370.
- Burm, Anton G. L.; Cohen, Imca M. C.; van Kleef, Jack W.; Vletter, Arie A.; Olieman, Wim; Groen, Kees (1 January 1997). "Pharmacokinetics of the Enantiomers of Mepivacaine After Intravenous Administration of the Racemate in Volunteers". Anesthesia & Analgesia. 84 (1): 85–9. doi:10.1097/00000539-199701000-00016. PMID 8989005. S2CID 22363370.
External links
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