Methylenediurea deaminase

Methylenediurea deaminase (EC 3.5.3.21, methylenediurease) is an enzyme with systematic name methylenediurea aminohydrolase found in Ochrobactrum anthropi, a bacterium.[1] This enzyme catalyses the following chemical reaction

methylenediurea + 2 H2O N-(hydroxymethyl)urea + 2 NH3 + CO2 (overall reaction)
(1a) methylenediurea + H2O N-(carboxyaminomethyl)urea + NH3
(1b) N-(carboxyaminomethyl)urea N-(aminomethyl)urea + CO2 (spontaneous)
(1c) N-(aminomethyl)urea + H2O N-(hydroxymethyl)urea + NH3 (spontaneous)
Methylenediurea deaminase
Identifiers
EC number3.5.3.21
CAS number205830-62-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Methylenediurea is hydrolysed and decarboxylated to give an aminated methylurea.

References

  1. Jahns T, Schepp R, Kaltwasser H (1997). "Purification and characterisation of an enzyme from a strain of Ochrobactrum anthroπ that degrades condensation products of urea and formaldehyde (ureaform)". Can. J. Microbiol. 43: 1111–1117. doi:10.1139/m97-159.
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