Metisazone
Methisazone (USAN) or metisazone (INN)[1] is an antiviral drug that works by inhibiting mRNA and protein synthesis, especially in pox viruses. It has been used in the past to treat smallpox.[2]
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Names | |
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IUPAC name
[(1-Methyl-2-oxoindol-3-ylidene)amino]thiourea | |
Other names
Metisazone | |
Identifiers | |
3D model (JSmol) |
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ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.016.016 ![]() |
EC Number |
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KEGG | |
MeSH | D008720 |
PubChem CID |
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UNII | |
CompTox Dashboard (EPA) |
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Properties | |
C10H10N4OS | |
Molar mass | 234.28 g/mol |
Pharmacology | |
J05AA01 (WHO) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Infobox references | |
Methisazone has been described as being used in prophylaxis since at least 1965.[3][4]
The condensation of N-methylisatin with thiosemicarbazide leads to methisazone.
References
- Aromatic thiosemicarbazones, their antiviral action and interferon. 1. The decreasing of adenovirus type 1 resistance against interferon by methisazone in vitro, Yuriy V. Patskovsky*, Emma N. Negrebetskaya, Alexandra A. Chernomaz, Tamara P. Voloshchuk, Eugeniy L. Rubashevsky, Oleg E. Kitam, Mikhail I. Tereshchenko, Lidiya N. Nosach, Anatoliy I. Potopalsky
- Methisazone Archived 2012-07-10 at Archive.today, Merriam-Webster's Medical Dictionary
- do Valle, LA; de Melo, PR; de Gomes, LF; Proença, LM (13 Nov 1965). "Methisazone in prevention of variola minor among contacts". Lancet. 2 (7420): 976–8. doi:10.1016/s0140-6736(65)92840-0. PMID 4159212.
- Weiss MM, Weiss PD, Mathisen G, Guze P (December 2004). "Rethinking smallpox". Clin. Infect. Dis. 39 (11): 1668–73. doi:10.1086/425745. PMID 15578369.
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