Mevaldate reductase (NADPH)
In enzymology, a mevaldate reductase (NADPH) (EC 1.1.1.33) is an enzyme that catalyzes the chemical reaction
- (R)-mevalonate + NADP+ mevaldate + NADPH + H+
| mevaldate reductase (NADPH) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.33 | ||||||||
| CAS number | 9028-34-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are (R)-mevalonate and NADP+, whereas its 3 products are mevaldate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NADP+ oxidoreductase. Other names in common use include mevaldate (reduced nicotinamide adenine dinucleotide phosphate), reductase, and mevaldate reductase (NADPH).
References
- Wolstenholme GE, O'Connor M, eds. (1959). CIBA Symposium on the Biosynthesis of Terpenes and Sterols. London. pp. 62–74.
- Jakoby WB, ed. (1980). Enzymatic Basis of Detoxication. 1. New York: Academic Press. pp. 249–260.
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