mir-938 microRNA precursor family

In molecular biology mir-938 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

mir-938
Identifiers
Symbolmir-938
RfamRF00964
miRBase familyMIPF0000469
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

miR-938 and the TGF-β pathway

miR-938 has been found to directly target the SMAD3 gene, which encodes the main downstream TGF-β polypeptide SMAD3. This microRNA is overexpressed in non-functioning pituitary adenomas (NFPAs) compared with normal pituitary tissue.[1] Downregulation of TGF-β signalling is likely to play a role in the regulation of signalling pathways in NFPA tumorigenesis, thus also implicating SMAD3 and miR-938.

See also

References

  1. Butz H, Likó I, Czirják S, Igaz P, Korbonits M, Rácz K, et al. (2011). "MicroRNA profile indicates downregulation of the TGFβ pathway in sporadic non-functioning pituitary adenomas". Pituitary. 14 (2): 112–24. doi:10.1007/s11102-010-0268-x. PMID 21063788.

Further reading

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