My Family

• Robert Lindsay (2000–11) portrays Ben Harper. Ben Harper is an overly-misanthropic and cynical dentist. When he is not at work sacking another assistant or trying to avoid fellow-dentist Roger, he is at home trying to relax (which never works). Ben isn't a bad man; behind his sardonic exterior he does really love his family and has to put up with being bossed about and manipulated by his wife Susan and continually fleeced for money by his children.[6]
• Zoë Wanamaker (2000–11) portrays Susan Harper. Susan Harper is a control freak and very good at getting her way. She is constantly worried about her three children and often forces Ben to go out of his way to monitor or look after them. Susan is a tour guide but seems to spend most of her time at home. She is a terrible cook. This is a homage to Butterflies, in which the male lead is also a dentist called Ben and the rest of the family often have to sneak the food she has prepared into the bin without her noticing.
• Kris Marshall (2000–05) portrays Nick Harper. Nick Harper is the oldest sibling. He is a layabout who is constantly changing jobs – a self-employed stuntman one minute, a gorilla-o-gram the next, at one point a sperm-donor. Extremely laid-back, Nick cannot be trusted to look after money or handle important tasks. He was last seen moving into his own flat, and from phone conversations Ben and Susan have with him, he seems to be coping with living on his own.
• Daniela Denby-Ashe (2000–02; 2004–11) portrays Janey Harper. Fashion-conscious, money-loving, boy-mad Janey spends all her time on the phone, switching boyfriends, or pestering Ben for shopping money. Whilst at Manchester University (spending yet more of her dad's money) Janey got pregnant. She was expelled and returned home to once again take advantage of her parents. Susan does not seem to mind, as it means she now has Kenzo Harper to look after.[6]
• Gabriel Thomson (2000–11) portrays Michael Harper. Michael (or "Mikey" as Ben calls him) is Susan and Ben's youngest, a smart, geeky adolescent. He looks down on his family, thinking he is more sensible than the rest of them put together, and often ends up getting them out of trouble. Since starting university he has experimented with bleached hair and piercings. In series 10 Michael comes out and tells his family that he is gay; he is relieved when they accept this.
• Siobhan Hayes (2002–08) portrays Abi Harper. Abi moved into the Harper household in the third series. She is Ben's first cousin once removed, very clumsy and very dim, and often seen telling off Ben or Susan. When she finally realized that Roger was madly in love with her, they married in series seven, but she later left him to become a nun.[6]
• Keiron Self (2002–11) portrays Roger Bailey. Roger is the over-enthusiastic dentist who works in the same building as Ben. He often turns up at the Harper household uninvited and proceeds to unintentionally annoy Ben. For a long period Roger was trying to build up the courage to ask Abi out. They were, after all, ideally suited – like Abi, Roger possesses no common sense and is gullible. Eventually they did marry but have since split as Abi has decided to become a nun. He's now a part-time policeman as well a dentist.[6]
• Rhodri Meilir (2005–09) portrays Alfie Butts. Alfie is a friend of Nick's who turned up at the Harper household at Christmas 2005. Alfie comes from a small community in Wales which, based on his stories, has some rather backwards traditions. Also, there weren't many girls where he came from, so he savors spending time at the Harpers' and meeting Michael's friends. Most of the family have turned to him at various times for advice. He's a struggling musician who is very laid-back about life despite not having a home or a steady income.[6] He did not appear in the 2009 Christmas special and was completely absent from the whole of series 10 and 11, with no explanation.
• Tayler Marshall (2006–11; character introduced in 2003) portrays Kenzo Harper. Kenzo is the youngest member of the Harper household, son of Janey, grandson of Ben and Susan and nephew of Michael and Nick. Even at such a young age, he's shown a massive intelligence which at times even rivals, and at times even beats, Michael's. At the end of series nine, he has done a project about his family and he tells them his teachers want him to see a psychologist. As portrayed by Tayler Marshall, Kenzo bears a striking resemblance to his uncle Nick (Kris Marshall).[7] Before becoming Kenzo in 2006, Tayler Marshall portrayed a guest at Kenzo's third-birthday party in 2005.

• Daisy Donovan portrays Brigitte McKay, Ben Harper's dental assistant for the entire first series. She was known for her unique way of thinking and living, and often tried to offer Ben and his patients spiritual guidance. She often forgot to take phone messages for Ben and irritated him while he worked. She and Nick appeared to be attracted to each other.
• Chloe Bale portrays Sasha, Janey's best friend in series 8–11. Storylines focused on the pair getting into trouble (usually instigated by Sasha). She was disliked by Ben, then by Janey until they became friends again.
• Maxine an unseen character was Janey's best friend from school. Although she was never seen, it was hinted that Maxine was very much like Janey: popular, and fashion-conscious. Janey once admitted to Susan that she hung out with Maxine because Maxine's alleged "ugliness" made Janey look more beautiful. Janey was also jealous that Maxine's parents treated her with expensive designer labels. It is unknown if they kept in touch.
• Rosemary Leach portrays Grace Riggs, Susan Harper's mother, known for her addiction to alcohol, especially martinis. She and Susan have a cold relationship, and are locked in a constant psychological battle. Grace has had various boyfriends in the show and was the one who told Ben that Susan was married before she married him. She likes to make Susan feel guilty for not visiting her and often uses deceitful tactics to lure her over. Her own late mother, Mary, owned a highly-successful brothel in London's West End. She first appeared in series two, played by Avril Elgar and credited as "Rebecca" (although she was not referred to by name in the episode). She did not reappear until Leach took up the role in series four. It was announced in the episode "A Decent Proposal" that she had died.
• Kevin Bishop portrays Stupid Brian, Janey's boyfriend in the show's second series when he and Janey were still at school but he was getting into decorating. Although he lived up to the nickname 'Stupid Brian,' he was surprising apt at building a bookshelf for the Harpers' kitchen.
• Alex Dawson portrays Hubert, Michael's best friend (it's unknown whether they're still in touch). Hubert was known for being very square but very smart. He once created a television remote that could gain 'free' access channels that required PINs for them.
• Andy Taylor portrays Hotel Receptionist, appearing in five episodes. He appears in different hotels across the country as a hotel receptionist. Each time he encountered the Harper family he became more familiar with their dysfunctional antics. He once suspected that Susan was an escort and that Ben had a mistress.
• Nickolas Grace portrays Mr. Casey, the Harpers' next-door neighbour, although he doesn't get along with them. Viewers first met him as a recent widower who had adopted a dog and named her Gemma. He also tried to scam Ben for money after Ben ran over this dog.
• Rachel Hyde-Harvey portrays Fiona, Michael's girlfriend throughout the fourth series. She and Michael are caught in bed together but never had sex. They are also caught kissing in the airing cupboard, and in another scene they begin to take their clothes off but Susan is listening and says they should stop.
• Nathan Brine portrays Scott Marsh in series 10. Scott is Michael's first boyfriend. In his first appearance, Ben accidentally outed him to his homophobic father and he was forced to leave home. Susan invited him to live at the house, but Michael and Scott moved into a new flat instead. A few episodes later, it was revealed that Scott and Michael had split up, although they got back together in the same episode.

My Family has used several actors from various past hit sitcoms, most notably David Haig from The Thin Blue Line, Belinda Lang of 2point4 Children, Diana Weston (Robert Lindsay's former long-term partner) from The Upper Hand who portrayed a trans woman named Charlie, Pauline Quirke of Birds of a Feather played a bank robber (whilst her husband in Birds of a Feather was a bank robber), and Sam Kelly from On the Up.

At the start of the first two series, it slides across four boxes with each character's face in them. The first box stands alone with Ben and Susan in it. The other three are lapped over each other with a photo of Michael, Janey and Nick from left to right in them. While it slides across at the start, each character's face turns with Janey and Nick smiling and the others being fairly plain faced. Once the boxes are placed, the boxes with youngsters in them drop to the bottom of the screen and are replaced with the show's logo.

At the start of the third series, four rectangle blocks fall onto a completely white screen to create Ben's face. Those blocks are then replaced with blocks that create Susan's face; each block then shows different parts of the other characters to finally reveal Nick's face. It continues to do this for Janey, Michael and (starting from the fourth episode entitled "Of Mice and Ben") the new character to the show Abi. Abi's (for the first three episodes, Michael's) face then falls into the bottom right corner while the previous faces spread across to other places of the white screen. It reveals that Nick, Janey and Michael are next to Abi and Ben and Susan are with each other at the top left of the screen. The logo fades on the top right of the screen.

The fourth series is similar to the third series opening sequence. Only difference is that the photo of each character is changed, each block does not show different parts of each character when it transitions; instead it transitions in various styles, for example in an opening in a window blind style. Series five titles still remain similar; the photos are changed again and there are eleven rectangles instead of four. Nick is almost completely absent from the opening titles in series five except in episode six of series five titled "My Will Be Done"; he was missing in some episodes from series four and a few from series three.

The series six opening titles have cut-outs of each character, as they fade into the white screen and zoom in and out and eventually stop moving. The line-up from left to right is Abi, Michael, Susan, Ben, Janey and Roger. The titles remain the same for series seven and eight; the one difference is that Janey's clothes are changed. In series nine, the line-up changes due to Abi's departure at the end of the previous series. Her place is taken by Alfie, who has been a regular since series six but never appeared in the titles until the ninth series. Starting in the 2009 Christmas Special, Alfie has been replaced by Kenzo.

• Fred Barron (2000–2003)
• Ian Brown & James Hendrie (2004–2005)
• Tom Leopold (2006)
• Tom Anderson (2007–2011)[8]