Mycothiol synthase

Mycothiol synthase (EC 2.3.1.189, MshD) is an enzyme with systematic name acetyl-CoA:desacetylmycothiol O-acetyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

desacetylmycothiol + acetyl-CoA CoA + mycothiol
Mycothiol synthase
Identifiers
EC number2.3.1.189
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme catalyses the last step in the biosynthesis of mycothiol

References

  1. Spies HS, Steenkamp DJ (August 1994). "Thiols of intracellular pathogens. Identification of ovothiol A in Leishmania donovani and structural analysis of a novel thiol from Mycobacterium bovis". European Journal of Biochemistry. 224 (1): 203–13. doi:10.1111/j.1432-1033.1994.tb20013.x. PMID 8076641.
  2. Koledin T, Newton GL, Fahey RC (November 2002). "Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes". Archives of Microbiology. 178 (5): 331–7. doi:10.1007/s00203-002-0462-y. PMID 12375100.
  3. Vetting MW, Roderick SL, Yu M, Blanchard JS (September 2003). "Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis shows structural homology to the GNAT family of N-acetyltransferases". Protein Science. 12 (9): 1954–9. doi:10.1110/ps.03153703. PMC 2323992. PMID 12930994.
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