N-acetylneuraminate epimerase

N-acetylneuraminate epimerase (EC 5.1.3.24, sialic acid epimerase, N-acetylneuraminate mutarotase, sialic acid mutarotase, YjhT, NanM) is an enzyme with systematic name N-acetyl-alpha-neuraminate 2-epimerase.[1] This enzyme catalyses the following chemical reaction

N-acetyl-alpha-neuraminate N-acetyl-beta-neuraminate
N-acetylneuraminate epimerase
Identifiers
EC number5.1.3.24
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Sialoglycoconjugates present in vertebrates are linked exclusively by alpha-linkages.

See also

References

  1. Severi E, Müller A, Potts JR, Leech A, Williamson D, Wilson KS, Thomas GH (February 2008). "Sialic acid mutarotation is catalyzed by the Escherichia coli beta-propeller protein YjhT". The Journal of Biological Chemistry. 283 (8): 4841–9. doi:10.1074/jbc.M707822200. PMID 18063573.
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