N-carbamoyl-L-amino-acid hydrolase

In enzymology, a N-carbamoyl-L-amino-acid hydrolase (EC 3.5.1.87) is an enzyme that catalyzes the chemical reaction

N-carbamoyl-L-2-amino acid (a 2-ureido carboxylate) + H2O L-2-amino acid + NH3 + CO2
N-carbamoyl-L-amino-acid hydrolase
Identifiers
EC number3.5.1.87
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are N-carbamoyl-L-2-amino acid and H2O, whereas its 3 products are L-2-amino acid, NH3, and CO2.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-carbamoyl-L-amino acid amidohydrolase.

References

    • Ogawa J, Miyake H, Shimizu S (1995). "Purification and characterization of N-carbamoyl-L-amino acid amidohydrolase with broad substrate specificity from Alcaligenes xylosoxidans". Appl. Microbiol. Biotechnol. 43 (6): 1039–43. doi:10.1007/BF00166922. PMID 8590654.


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