NLRP14

NLRP14, short for NOD-like receptor family pyrin domain containing 14, is an intracellular protein of mammals associated with a role in spermatogenesis. It is also known as NALP14, NOD5, GC-LRR, Nalp-iota, PAN8, and CLR11.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.[5] NLRP14 is found exclusively in the testes where it is expressed within spermatogonia, spermatocytes and spermatids.[6]

NLRP14
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNLRP14, CLR11.2, GC-LRR, NALP14, NOD5, PAN8, NLR family, pyrin domain containing 14, NLR family pyrin domain containing 14
External IDsOMIM: 609665 MGI: 1924108 HomoloGene: 18531 GeneCards: NLRP14
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11p15.4Start7,020,446 bp[1]
End7,071,308 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

338323

76858

Ensembl

ENSG00000158077

ENSMUSG00000016626

UniProt

Q86W24

Q6B966

RefSeq (mRNA)

NM_176822

NM_001002894

RefSeq (protein)

NP_789792

NP_001002894

Location (UCSC)Chr 11: 7.02 – 7.07 MbChr 7: 107.17 – 107.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

  1. GRCh38: Ensembl release 89: ENSG00000158077 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000016626 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.
  6. Westerveld GH, Korver CM, van Pelt AM, et al. (December 2006). "Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure". Hum. Reprod. 21 (12): 3178–84. doi:10.1093/humrep/del293. PMID 16931801.

Further reading

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human NACHT, LRR and PYD domains-containing protein 14 (NLRP14)


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