NSL1

Kinetochore-associated protein NSL1 homolog is a protein that in humans is encoded by the NSL1 gene.[5]

NSL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNSL1, C1orf48, MIS14, DC8, MIS12 kinetochore complex component, NSL1 component of MIS12 kinetochore complex
External IDsOMIM: 609174 MGI: 2685830 HomoloGene: 22898 GeneCards: NSL1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q32.3Start212,726,153 bp[1]
End212,791,782 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

25936

381318

Ensembl

ENSG00000117697

ENSMUSG00000062510

UniProt

Q96IY1

Q8K305

RefSeq (mRNA)

NM_015471
NM_001042549
NM_001297736
NM_001297737
NM_001297739

NM_198654

RefSeq (protein)

NP_001036014
NP_001284665
NP_001284666
NP_001284668
NP_056286

n/a

Location (UCSC)Chr 1: 212.73 – 212.79 MbChr 1: 191.06 – 191.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene.[5]

Interactions

NSL1 has been shown to interact with MIS12[6] and DSN1.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000117697 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000062510 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: NSL1 NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)".
  6. Obuse, Chikashi; Iwasaki Osamu; Kiyomitsu Tomomi; Goshima Gohta; Toyoda Yusuke; Yanagida Mitsuhiro (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. England. 6 (11): 1135–41. doi:10.1038/ncb1187. ISSN 1465-7392. PMID 15502821. S2CID 39408000.

Further reading


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