DSN1

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae), also known as DSN1 or MIS13, is a protein which in humans encoded by the DSN1 gene.[5][6]

DSN1
Identifiers
AliasesDSN1, C20orf172, KNL3, MIS13, dJ469A13.2, hKNL-3, DSN1 homolog, MIS12 kinetochore complex component, DSN1 component of MIS12 kinetochore complex
External IDsOMIM: 609175 MGI: 1914184 HomoloGene: 49806 GeneCards: DSN1
Gene location (Human)
Chr.Chromosome 20 (human)[1]
Band20q11.23Start36,751,791 bp[1]
End36,773,818 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

79980

66934

Ensembl

ENSG00000149636

ENSMUSG00000027635

UniProt

Q9H410

Q9CYC5

RefSeq (mRNA)

NM_001145315
NM_001145316
NM_001145317
NM_001145318
NM_024918

NM_025853

RefSeq (protein)

NP_001138787
NP_001138788
NP_001138789
NP_001138790
NP_079194

NP_080129

Location (UCSC)Chr 20: 36.75 – 36.77 MbChr 2: 157 – 157.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

DSN1 along with MIS12, DC8, PMF1, CBX5, ZWINT is a component of the kinetochore-associated multiprotein complex which is required for correct chromosome alignment during the metaphase of cell mitosis.[6][7]

Interactions

DSN1 has been shown to interact with NSL1[8] and MIS12.[6][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000149636 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027635 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: DSN1 DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)".
  6. Obuse C, Iwasaki O, Kiyomitsu T, Goshima G, Toyoda Y, Yanagida M (November 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821. S2CID 39408000.
  7. Yang Y, Wu F, Ward T, Yan F, Wu Q, Wang Z, McGlothen T, Peng W, You T, Sun M, Cui T, Hu R, Dou Z, Zhu J, Xie W, Rao Z, Ding X, Yao X (September 2008). "Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore". J. Biol. Chem. 283 (39): 26726–36. doi:10.1074/jbc.M804207200. PMC 2546542. PMID 18640974.
  8. Obuse, Chikashi; Iwasaki Osamu; Kiyomitsu Tomomi; Goshima Gohta; Toyoda Yusuke; Yanagida Mitsuhiro (Nov 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. England. 6 (11): 1135–41. doi:10.1038/ncb1187. ISSN 1465-7392. PMID 15502821. S2CID 39408000.
  9. Cheeseman, Iain M; Niessen Sherry; Anderson Scott; Hyndman Francie; Yates John R; Oegema Karen; Desai Arshad (Sep 2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension". Genes Dev. United States. 18 (18): 2255–68. doi:10.1101/gad.1234104. ISSN 0890-9369. PMC 517519. PMID 15371340.

Further reading


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