Nucleoside-triphosphatase

In enzymology, a nucleoside-triphosphatase (NTPase) (EC 3.6.1.15) is an enzyme that catalyzes the chemical reaction

NTP + H2O NDP + phosphate
nucleoside-triphosphatase
Identifiers
EC number3.6.1.15
CAS number9075-51-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are NTP and H2O, whereas its two products are NDP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is unspecific diphosphate phosphohydrolase. Other names in common use include nucleoside triphosphate phosphohydrolase, nucleoside-5-triphosphate phosphohydrolase, and nucleoside 5-triphosphatase. This enzyme participates in purine metabolism and thiamine metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2I3B.

References

    • Brightwell R, Tappel AL (1968). "Lysosomal acid pyrophosphatase and acid phosphatase". Arch. Biochem. Biophys. 124 (1): 333–43. doi:10.1016/0003-9861(68)90335-4. PMID 5661608.
    • LEWIS M, WEISSMAN S (1965). "Properties of a soluble nucleoside triphosphatase activity in mammalian liver". Arch. Biochem. Biophys. 109 (3): 490–8. doi:10.1016/0003-9861(65)90393-0. PMID 14320490.
    • Matsushita S, Raacke ID (1968). "Purification of nucleoside triphosphatases from pea seedling ribosomes". Biochim. Biophys. Acta. 166 (3): 707–10. doi:10.1016/0005-2787(68)90380-8. PMID 4301913.


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