One Life to Live storylines (1968–1979)

Young intern Dr. Larry Wolek (Paul Tulley, Jim Storm, from 1969 onward Michael Storm) falls in love with Meredith Lord (Trish Van Devere, Lynn Benesch) the younger of two daughters of Victor Lord (Ernest Graves, Shepperd Strudwick). They initially met when Larry helped treat Merrie's heart condition. Victor disapproved of Larry as a suitor for his daughter and forbade her seeing him. Frustrated, Larry turned to Karen Martin (Niki Flacks), a nurse who saved his life when he was trapped in a fire. Larry wed Karen, but realized soon afterward it was a mistake; he didn't love her. He did stay with her when he found out she was pregnant however. Meanwhile, a heart-broken Merrie became involved with Tom Edwards (Joseph Gallison), a young man whom she found wandering in the park with amnesia and who was more to Victor's liking. Karen miscarried her baby and agreed to a divorce. Larry wanted to court Merrie again, but she had already accepted Tom's proposal. Ultimately though, Merrie chose to wed Larry. Merrie went through her own extremely difficult pregnancy, but successfully delivered twins, a son Danny (who would eventually grow up to be a doctor as well) and a daughter who died at birth. She suffered from post-partum depression. She was also held hostage by two escaped convicts for a prolonged period. Tragically, she died of a brain aneurysm in 1973, leaving Larry crushed.

Merrie's sister Victoria Lord (originated by Gillian Spencer, from 1971 onward Erika Slezak) was a sexually repressed young woman who lived for her father's approval. When brash reporter Joe Riley (Lee Patterson) began to chip away at her defenses, the fun-loving red-wigged "Niki Smith" began showing up at local bars. Joe's best friend, truck-driver (and later police officer) Vinny Wolek (Antony Ponzini, Jordan Charney, Michael Ingram), fell in love with Niki. When he realized she was really a split-personality (or 'alter') of Viki, he told Joe the truth. Viki underwent psychoanalysis with Dr. Polk, and her split-personality seemed at the time to be cured. She married Joe soon afterward. A few years later, Joe was presumed dead. Viki married reporter Steve Burke (Bernard Grant), who at the time was being stalked by the psychopathic Marcy Wade (Francesca James). Steve went on trial for her murder, and was ultimately cleared by none other than Joe himself, who had survived his presumably fatal car crash, but had been amnesiac for over a year. Poor Viki suddenly found herself with two husbands, and had a difficult time deciding on which husband to stay married. Viki and Joe reunited, but not before he had a child with Cathy Craig (Dorrie Kavanaugh). When the child died, Cathy kidnapped Viki and Joe's baby, Kevin Riley, in 1977.

OLTL was the first soap opera to have a racially integrated cast. Additionally, it was the first to deal with interracial relationships. The character of Carla Gray (Ellen Holly) was an African American woman trying to pass for white. Her mother, Sadie Gray (Lillian Hayman, Esther Rolle), who was the neighbor and friend to the Woleks and worked in the Housekeeping Department at the hospital (she later became Head of Housekeeping there), discovered her daughter, Clara, was pretending to be a white woman, and eventually persuaded her to reveal her true racial identity.

The show also had a sustained anti-drug storyline centering on wild child Cathy Craig (Catherine Burns, Dorrie Kavanaugh, Jennifer Harmon). Cathy was the only daughter of widower Dr. Jim Craig (Robert Milli, Nat Polen). She resented her father's second marriage to Anna Wolek (Doris Belack, Kathleen Maguire, Phyllis Behar). Cathy rebelled by taking drugs, and spiralled into addiction. While on a bad acid trip, she murdered her drug dealer Artie Duncan (John Cullum), but blocked the incident out of her memory. Vinnie was wrongly accused and sentenced for the crime. Cathy finally recalled her actions and confessed. Rather than go to jail, she was sent to Odyssey House, a real-life NYC treatment center for drug-addicted youths. In an unusual move, Cathy's portrayer, actress Amy Levitt, was videotaped while sitting in on real-life therapy sessions at Odyssey House, which were then broadcast as OLTL episodes during the summer of 1970.

Dr. Dorian Cramer (Nancy Pinkerton, on-and-off from 1979 Robin Strasser) arrived in Llanview in April 1973 with her sister, Melinda (Patricia Pearcy); the following year she and her married lover Dr. Mark Toland (Tommy Lee Jones) conspired to cover up their complicity in the death of patient, Rachel Wilson (Nancy Barrett). When the truth came out, Dorian was suspended from Llanview hospital; erroneously believing Viki was partly responsible, Dorian vowed revenge. After becoming the private physician to Viki's ailing father Victor, she married him, and schemed to control his fortune. Dorian's machinations further fueled the enmity between Viki and herself. After Victor's mysterious death in 1976, the shadow of suspicion surrounded Dorian for decades.

As social issue-oriented stories on matters such as race and drug addiction played themselves out, ratings fell; in response, in 1975 ABC hired high-priced Another World actors George Reinholt and Jacqueline Courtney to portray Tony Lord and Pat Ashley. The numbers rose, but the pairing never achieved the success expected by executives. Reinholt left after only two years and replaced by Philip MacHale and, later, Chip Lucia; Courtney was fired in 1983.

The show did have huge success in the middle and late 1970s with new character-siblings Jenny (Katherine Glass, Brynn Thayer) and Karen Wolek (Kathryn Breech, Julia Duffy, Judith Light), distant cousins of the original Wolek family. Jenny was a novitiate nun who left the convent after falling in love with Tim Siegel (Tom Berenger). Her cousin Vinnie was angry, and accused Tim of 'stealing Jenny from the church.' Vinnie & Tim got into a physical fight, one that left Tim with grave head injuries from which he died soon afterwards. Jenny married Tim on his deathbed. Later, Jenny married bad boy Brad Vernon (Steve Fletcher, Jameson Parker), a philandering Lothario who caused her no small amount of grief.

Karen seduced Larry into marrying her, a controversial move in itself given that they were related (albeit several familial relations removed). But Karen, bored with married life and suffering overwhelming self-esteem problems, began turning tricks in the daytime with rich suitors in exchange for expensive 'gifts.' The sleazy opportunist Marco Dane (Gerald Anthony) discovered Karen's trysts and blackmailed her into becoming a housewife hooker, turning tricks for his clientele while Larry was at work. Karen was overwhelmed with guilt, and finally confessed to Viki her secret life. Viki helped Karen escape Marco's control.

Also appearing for the first time in 1978 was Viki's teenage ward Tina Clayton (Andrea Evans), introduced as the orphaned daughter of Viki's college friend Irene Manning Clayton (Kate McKeown) who asked Viki to be Tina's guardian before she died. Red-headed, free-spirited Tina seemed quite a lot like Viki's alter-ego Niki Smith, and was almost as troublesome. Nevertheless, Viki did her best to be a good mother figure to Tina. It would be years later that the two women learned how close their bond really was.

Jenny was delighted to be pregnant with Brad's baby. Brad had developed a compulsion for gambling. With his losses mounting, Brad stole Jenny's key to the hospital's pharmacy. Brad gave the key to a mobster named Brick in exchange for forgiving Brad's gambling debts. When Brick and an accomplice tried to rob the pharmacy, they were caught by Dr. Jack Scott(Arthur Burghardt), who was shot and paralyzed in the violent exchange.

Feeling guilty Brad was home alone without her, Jenny asked Karen to look after him. Karen knew Brad did not like her, but Karen would do whatever Jenny wanted. Brad and Karen clashed at first, but eventually Brad became fascinated by his sexy sister-in-law. The fascination grew into obsession. One night, Brad tried to seduce his sister-in-law, but the seduction turned to rape. Karen knew she couldn't reveal a word about the rape because if Jenny were to find out, it would all but destroy her. Larry began his own detective work and realized Brad raped Karen. In a rage, Larry beat Brad to a pulp. Jenny threw Brad out of their apartment. He pleaded guilty to a lesser charge, and was sentenced to three months in prison.

Jenny gave premature birth to her tiny baby about the same time Katrina gave birth to her own healthy baby. When Karen and Marco were visiting the hospital, Jenny's baby went into cardiac arrest and died before their eyes. In a panic, Karen and Marco switched Jenny's baby with Katrina's baby. Katrina fell into a deep depression when she was told her baby died. Jenny took baby Mary home, never suspecting the precious little girl belonged to another woman.

When Pat discovered her new husband Adam Brewster(John Mansfield) had put all moral considerations aside in order to get his financial empire back in order, she quickly had their new marriage annulled. For comfort, Pat turned to her TV producer, Dick Grant(A.C. Weary). In Pat's presence, Dick was a cheerful, charming, very outgoing gentleman. However, unbeknownst to Pat, Dick had developed a psychotic crush on her. When Samantha discovered Dick had turned his apartment into a photo-covered shrine to Pat, he kidnapped her, and then Pat, before the police apprehended him.

Viki received some joyous news when she discovered she was pregnant with her second child. Joe began suffering all the classic signs of a recurrence of his brain tumor. When Joe learned he had only a few weeks left, he treated Viki to a wonderful wedding anniversary. With time running out, Joe hand-picked his successor as editor of The Banner. He sent for the editor of a small but prestigious newspaper in Arizona. The man's name was Clint Buchanan (Clint Ritchie). Joe broke the news of his prognosis to Viki, shortly before succumbing to his illness. He beseeched Viki to move on with her life after he was gone. Viki poured her energies into working with Clint at The Banner, and fending off a takeover attempt by her arch-rival, Dorian Lord.