PARP10

PARP10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DHX, 3HKV
Identifiers
Aliases	PARP10, ARTD10, poly(ADP-ribose) polymerase family member 10
External IDs	OMIM: 609564 MGI: 3712326 HomoloGene: 53133 GeneCards: PARP10
Gene location (Human)
Chr.	Chromosome 8 (human)[1]
End	144,012,772 bp[1]
Gene ontology
Molecular function	• transferase activity; • K63-linked polyubiquitin modification-dependent protein binding; • GO:0001948 protein binding; • transferase activity, transferring glycosyl groups; • NAD+ ADP-ribosyltransferase activity; • protein ADP-ribosylase activity;
Cellular component	• cytoplasm; • cell nucleus; • nucleolus; • cytosol; • intracellular membrane-bounded organelle;
Biological process	• negative regulation of protein K63-linked ubiquitination; • protein auto-ADP-ribosylation; • regulation of chromatin assembly; • negative regulation of NF-kappaB transcription factor activity; • protein ADP-ribosylation; • negative regulation of fibroblast proliferation; • negative regulation of gene expression; • NAD biosynthesis via nicotinamide riboside salvage pathway; • protein poly-ADP-ribosylation; • translesion synthesis; • protein mono-ADP-ribosylation; • DNA repair; • cellular response to DNA damage stimulus;
	Sources:Amigo / QuickGO
Orthologs
	84875
	671535
	ENSG00000178685
	ENSMUSG00000063268
	Q53GL7
	Q8CIE4
	NM_032789; NM_001317895
	NM_001163575; NM_001163576
	NP_001304824; NP_116178
	NP_001157047; NP_001157048
	Wikidata
View/Edit Human	View/Edit Mouse

Poly [ADP-ribose] polymerase 10 is an enzyme that in humans is encoded by the PARP10 gene.[4][5]

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005).[supplied by OMIM][5]

References

GRCh38: Ensembl release 89: ENSG00000178685 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ame JC, Spenlehauer C, de Murcia G (Jul 2004). "The PARP superfamily". BioEssays. 26 (8): 882–93. doi:10.1002/bies.20085. PMID 15273990. S2CID 25024719.
"Entrez Gene: PARP10 poly (ADP-ribose) polymerase family, member 10".

Chou HY, Chou HT, Lee SC (2006). "CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10)". J. Biol. Chem. 281 (22): 15201–7. doi:10.1074/jbc.M506745200. PMID 16455663.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Yu M, Schreek S, Cerni C, et al. (2005). "PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation". Oncogene. 24 (12): 1982–93. doi:10.1038/sj.onc.1208410. PMID 15674325.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178685 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15273990-4] Ame JC, Spenlehauer C, de Murcia G (Jul 2004). "The PARP superfamily". BioEssays. 26 (8): 882–93. doi:10.1002/bies.20085. PMID 15273990. S2CID 25024719.

[entrez-5] "Entrez Gene: PARP10 poly (ADP-ribose) polymerase family, member 10".

PARP10

References

Further reading