PARP10

Poly [ADP-ribose] polymerase 10 is an enzyme that in humans is encoded by the PARP10 gene.[4][5]

PARP10
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPARP10, ARTD10, poly(ADP-ribose) polymerase family member 10
External IDsOMIM: 609564 MGI: 3712326 HomoloGene: 53133 GeneCards: PARP10
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q24.3Start143,977,153 bp[1]
End144,012,772 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

84875

671535

Ensembl

ENSG00000178685

ENSMUSG00000063268

UniProt

Q53GL7

Q8CIE4

RefSeq (mRNA)

NM_032789
NM_001317895

NM_001163575
NM_001163576

RefSeq (protein)

NP_001304824
NP_116178

NP_001157047
NP_001157048

Location (UCSC)Chr 8: 143.98 – 144.01 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005).[supplied by OMIM][5]

References

  1. GRCh38: Ensembl release 89: ENSG00000178685 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Ame JC, Spenlehauer C, de Murcia G (Jul 2004). "The PARP superfamily". BioEssays. 26 (8): 882–93. doi:10.1002/bies.20085. PMID 15273990. S2CID 25024719.
  5. "Entrez Gene: PARP10 poly (ADP-ribose) polymerase family, member 10".

Further reading


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