Potency (pharmacology)

In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.[1] A highly potent drug (e.g., fentanyl, alprazolam, risperidone) evokes a given response at low concentrations, while a drug of lower potency (meperidine, diazepam, ziprasidone) evokes the same response only at higher concentrations. Higher potency does not necessarily mean more side effects.

Concentration-response curves illustrating the concept of potency. For a response of 0.25a.u., Drug B is more potent, as it generates this response at a lower concentration. For a response of 0.75a.u., Drug A is more potent. a.u. refers to "arbitrary units".

The IUPHAR has stated that 'potency' is "an imprecise term that should always be further defined",[1] for instance as , , , and so on.

See also

References
  1. Neubig, RR; Spedding, M; Kenakin, T; Christopoulos, A; International Union of Pharmacology Committee on Receptor Nomenclature and Drug, Classification (December 2003). "International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology". Pharmacological Reviews. 55 (4): 597–606. doi:10.1124/pr.55.4.4. PMID 14657418.

Further reading
  • Harris, Robert (2012-10-09). "Formulating High Potency Drugs". Contract Pharma. Retrieved 2013-11-13.
  • Walker MG, Page CP, Hoffman BF, Curtis M (2006). Integrated Pharmacology (3rd ed.). St. Louis: Mosby. ISBN 978-0-323-04080-8.
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