SMARCA1

Probable global transcription activator SNF2L1 is a protein that in humans is encoded by the SMARCA1 gene.[5][6][7]

SMARCA1
Identifiers
AliasesSMARCA1, ISWI, NURF140, SNF2L, SNF2L1, SNF2LB, SNF2LT, SWI, SWI2, hSNF2L, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
External IDsOMIM: 300012 MGI: 1935127 HomoloGene: 55711 GeneCards: SMARCA1
Gene location (Human)
Chr.X chromosome (human)[1]
BandXq25-q26.1Start129,446,501 bp[1]
End129,523,500 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6594

93761

Ensembl

ENSG00000102038

ENSMUSG00000031099

UniProt

P28370

Q6PGB8

RefSeq (mRNA)

NM_001290708
NM_053123
NM_001358618
NM_001358619

RefSeq (protein)

NP_001277637
NP_444353
NP_001345547
NP_001345548

Location (UCSC)Chr X: 129.45 – 129.52 MbChr X: 47.81 – 47.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Two transcript variants encoding different isoforms have been found for this gene.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000102038 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000031099 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Okabe I, Bailey LC, Attree O, Srinivasan S, Perkel JM, Laurent BC, Carlson M, Nelson DL, Nussbaum RL (Oct 1992). "Cloning of human and bovine homologs of SNF2/SWI2: a global activator of transcription in yeast S. cerevisiae". Nucleic Acids Res. 20 (17): 4649–55. doi:10.1093/nar/20.17.4649. PMC 334196. PMID 1408766.
  6. Barak O, Lazzaro MA, Lane WS, Speicher DW, Picketts DJ, Shiekhattar R (Nov 2003). "Isolation of human NURF: a regulator of Engrailed gene expression". EMBO J. 22 (22): 6089–100. doi:10.1093/emboj/cdg582. PMC 275440. PMID 14609955.
  7. "Entrez Gene: SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1".

Further reading

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