SNX2

SNX2
Identifiers
Aliases	SNX2, TRG-9, sorting nexin 2
External IDs	OMIM: 605929 MGI: 1915054 HomoloGene: 2332 GeneCards: SNX2
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	122,834,543 bp[1]
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)[2]
End	53,220,865 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• protein homodimerization activity; • insulin receptor binding; • leptin receptor binding; • epidermal growth factor receptor binding; • GO:0001948 protein binding; • phosphatidylinositol binding; • protein heterodimerization activity; • transferrin receptor binding; • lipid binding; • cadherin binding;
Cellular component	• cytoplasm; • cell projection; • early endosome membrane; • membrane; • retromer, tubulation complex; • Retromer; • endosome membrane; • lamellipodium; • extrinsic component of membrane; • cytosol; • lysosome; • endosome; • macromolecular complex;
Biological process	• endocytosis; • vesicle organization; • early endosome to Golgi transport; • retrograde transport, endosome to Golgi; • protein oligomerization; • protein transport; • intracellular protein transport; • lamellipodium morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	6643
	67804
	ENSG00000205302
	ENSMUSG00000034484
	O60749
	Q9CWK8
	NM_003100; NM_001278199
	NM_026386; NM_001357463
	NP_001265128; NP_003091
	NP_080662; NP_001344392
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.[5][6]

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.[6]

Interactions

SNX2 has been shown to interact with FNBP1.[7][8]

References

GRCh38: Ensembl release 89: ENSG00000205302 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000034484 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Molecular and Cellular Biology. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.
"Entrez Gene: SNX2 sorting nexin 2".
Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A (Nov 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Letters. 554 (1–2): 10–6. doi:10.1016/S0014-5793(03)01063-9. PMID 14596906. S2CID 19552309.
Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A (Jul 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8756–61. doi:10.1073/pnas.121433898. PMC 37508. PMID 11438682.

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI (Dec 2000). "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes". Molecular Biology of the Cell. 11 (12): 4105–16. doi:10.1091/mbc.11.12.4105. PMC 15060. PMID 11102511.
Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ (Jun 2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". The Journal of Biological Chemistry. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.
Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A (Jul 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8756–61. doi:10.1073/pnas.121433898. PMC 37508. PMID 11438682.
Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (Aug 2001). "A large family of endosome-localized proteins related to sorting nexin 1". The Biochemical Journal. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A (Nov 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Letters. 554 (1–2): 10–6. doi:10.1016/S0014-5793(03)01063-9. PMID 14596906. S2CID 19552309.
Gullapalli A, Garrett TA, Paing MM, Griffin CT, Yang Y, Trejo J (May 2004). "A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking". Molecular Biology of the Cell. 15 (5): 2143–55. doi:10.1091/mbc.E03-09-0711. PMC 404011. PMID 14978220.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Schaaf CP, Benzing J, Schmitt T, Erz DH, Tewes M, Bartram CR, Janssen JW (Feb 2005). "Novel interaction partners of the TPR/MET tyrosine kinase". FASEB Journal. 19 (2): 267–9. doi:10.1096/fj.04-1558fje. PMID 15546961. S2CID 17142907.
Abdul-Ghani M, Hartman KL, Ngsee JK (Jul 2005). "Abstrakt interacts with and regulates the expression of sorting nexin-2". Journal of Cellular Physiology. 204 (1): 210–8. doi:10.1002/jcp.20285. PMC 2963638. PMID 15690390.
Carlton JG, Bujny MV, Peter BJ, Oorschot VM, Rutherford A, Arkell RS, Klumperman J, McMahon HT, Cullen PJ (Oct 2005). "Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport". Journal of Cell Science. 118 (Pt 19): 4527–39. doi:10.1242/jcs.02568. PMC 1904489. PMID 16179610.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Rojas R, Kametaka S, Haft CR, Bonifacino JS (Feb 2007). "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors". Molecular and Cellular Biology. 27 (3): 1112–24. doi:10.1128/MCB.00156-06. PMC 1800681. PMID 17101778.
Skånland SS, Wälchli S, Utskarpen A, Wandinger-Ness A, Sandvig K (Mar 2007). "Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins". Traffic. 8 (3): 297–309. doi:10.1111/j.1600-0854.2006.00527.x. hdl:10852/11339. PMID 17319803. S2CID 21600584.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000205302 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034484 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9819414-5] Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Molecular and Cellular Biology. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.

[entrez-6] "Entrez Gene: SNX2 sorting nexin 2".

[pmid14596906-7] Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A (Nov 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Letters. 554 (1–2): 10–6. doi:10.1016/S0014-5793(03)01063-9. PMID 14596906. S2CID 19552309.

[pmid11438682-8] Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A (Jul 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8756–61. doi:10.1073/pnas.121433898. PMC 37508. PMID 11438682.

Sorting nexins
SNX-BAR	SNX1 SNX2 SNX4 SNX5 SNX6 SNX7 SNX8 SNX9 SNX18 SNX30 SNX32 SNX33
SNX-PX	SNX3 SNX10 SNX11 SNX12 SNX16 SNX20 SNX21 SNX22 SNX24 SNX29
SNX-Other	SNX13 SNX14 SNX15 SNX17 SNX19 SNX23 SNX25 SNX26 SNX27 SNX28 SNX31
Related articles	PX domain BAR domain Retromer

SNX2

Function

Interactions

References

Further reading