Small Cajal body specific RNA 6

Small Cajal body specific RNA 6 (also known as SCARNA6 or U88) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U5 spliceosomal RNA.

Small Cajal body specific RNA 6
Predicted secondary structure and sequence conservation of SCARNA6
Identifiers
Symbol	SCARNA6
Alt. Symbols	U88
Rfam	RF00478
Other data
RNA type	Gene; snRNA; snoRNA; scaRNA
Domain(s)	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0000275
PDB structures	PDBe

scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12[1]

U88 is found associated with both fibrillarin and Gar1p and co-localises with coilin in Cajal bodies.[1] It is an unusual guide RNA in that it is composed of both H/ACA box and a C/D box conserved domains. It is predicted to guide 2'-O-methylation of residue U41 of the U5 snRNA.[1]

U88 is also closely related to other human snoRNAs scaRNA U87 and a mouse homologue MBI-46.[2] In the human genome both U88 and U87 scaRNAs share the same host gene.[1][3]