Spirapril
Spirapril, sold under the brand name Renormax among others, is an ACE inhibitor antihypertensive drug used to treat hypertension. It belongs to dicarboxy group of ACE inhibitors.
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| Trade names | Renormax |
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| Routes of administration | Oral |
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| Bioavailability | 50% |
| Metabolism | converted to spiraprilat |
| Elimination half-life | 30 to 35 hours |
| Excretion | Hepatic and renal |
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| Formula | C22H30N2O5S2 |
| Molar mass | 466.61 g·mol−1 |
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It was patented in 1980 and approved for medical use in 1995.[1]
Chemistry
Like many ACE inhibitors, this prodrug is converted to the active metabolite spiraprilat following oral administration. Unlike other members of the group, it is eliminated both by renal and hepatic routes, which may allow for greater use in patients with renal impairment.[2] However, data on its effect upon the renal function are conflicting.[3]
References
- Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 468. ISBN 9783527607495.
- Shohat J, Wittenberg C, Erman A, Rosenfeld J, Boner G (1999). "Acute and chronic effects of spirapril, alone or in combination with isradipine on kidney function and blood pressure in patients with reduced kidney function and hypertension". Scand J Urol Nephrol. 33 (1): 57–62. doi:10.1080/003655999750016294. PMID 10100366.
- Noble S, Sorkin E (1995). "Spirapril. A preliminary review of its pharmacology and therapeutic efficacy in the treatment of hypertension". Drugs. 49 (5): 750–66. doi:10.2165/00003495-199549050-00008. PMID 7601014.
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