Surfactant protein D

SFTPD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1B08, 1M7L, 1PW9, 1PWB, 2GGU, 2GGX, 2ORJ, 2ORK, 2OS9, 2RIA, 2RIB, 2RIC, 2RID, 2RIE, 3DBZ, 3G81, 3G83, 3G84, 3IKN, 3IKP, 3IKQ, 3IKR, 4E52, 4M17, 4M18
Identifiers
Aliases	SFTPD, COLEC7, PSP-D, SFTP4, SP-D, surfactant protein D
External IDs	OMIM: 178635 MGI: 109515 HomoloGene: 2272 GeneCards: SFTPD
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	79,982,614 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	41,185,149 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • carbohydrate binding; • identical protein binding; • lipopolysaccharide binding; • monosaccharide binding;
Cellular component	• cytoplasm; • collagen; • endoplasmic reticulum membrane; • clathrin-coated endocytic vesicle; • endocytic vesicle; • extracellular region; • lysosome; • extracellular; • multivesicular body; • rough endoplasmic reticulum;
Biological process	• surfactant homeostasis; • cellular protein metabolic process; • positive regulation of phagocytosis; • immune system process; • receptor-mediated endocytosis; • respiratory gaseous exchange; • reactive oxygen species metabolic process; • regulation of cytokine production; • negative regulation of T cell proliferation; • macrophage chemotaxis; • defense response to bacterium; • regulation of immune response; • lung alveolus development; • innate immune system; • toll-like receptor signaling pathway; • induction of bacterial agglutination; • negative regulation by host of symbiont molecular function; • regulation of adhesion of symbiont to host epithelial cell; • developmental process;
	Sources:Amigo / QuickGO
Orthologs
	6441
	20390
	ENSG00000133661
	ENSMUSG00000021795
	P35247
	P50404
	NM_003019
	NM_009160
	NP_003010
	NP_033186
	Wikidata
View/Edit Human	View/Edit Mouse

Surfactant protein D, also known as SP-D, is a lung surfactant protein part of the collagenous family of proteins called collectin.[5] In humans, SP-D is encoded by the SFTPD gene[6][7] and is part of the innate immune system.[8][9] Each SP-D subunit is composed of an N-terminal domain, a collagenous region, a nucleating neck region, and a C-terminal lectin domain.[5][10] Three of these subunits assemble to form a homotrimer, which further assemble into a tetrameric complex.[5][10]

Interactions

Surfactant protein D has been shown to interact with DMBT1,[11][12] and hemagglutinin of influenza A virus.[13] Post-translational modification of SP-D i.e. S-nitrosylation switches its function.[14][15][16]

References

GRCh38: Ensembl release 89: ENSG00000133661 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021795 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hoppe HJ, Barlow PN, Reid KB (May 1994). "A parallel three stranded alpha-helical bundle at the nucleation site of collagen triple-helix formation". FEBS Letters. 344 (2–3): 191–5. doi:10.1016/0014-5793(94)00383-1. PMID 8187882.
Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, et al. (October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Archives of Biochemistry and Biophysics. 290 (1): 116–26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081.
Lu J, Willis AC, Reid KB (June 1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". The Biochemical Journal. 284. 284 (3): 795–802. doi:10.1042/bj2840795. PMC 1132609. PMID 1339284.
"Entrez Gene: SFTPD surfactant, pulmonary-associated protein D".
Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME (May 2008). "Surfactant protein D alters allergic lung responses in mice and human subjects". The Journal of Allergy and Clinical Immunology. 121 (5): 1140–1147.e2. doi:10.1016/j.jaci.2008.02.011. PMC 4145593. PMID 18355911.
Crouch E, Persson A, Chang D, Heuser J (June 1994). "Molecular structure of pulmonary surfactant protein D (SP-D)". The Journal of Biological Chemistry. 269 (25): 17311–9. PMID 8006040.
Tino MJ, Wright JR (April 1999). "Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner". American Journal of Respiratory Cell and Molecular Biology. 20 (4): 759–68. doi:10.1165/ajrcmb.20.4.3439. PMID 10101009. S2CID 29437779.
Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, et al. (May 1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". The Journal of Biological Chemistry. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228.
Goh BC, Rynkiewicz MJ, Cafarella TR, White MR, Hartshorn KL, Allen K, et al. (November 2013). "Molecular mechanisms of inhibition of influenza by surfactant protein D revealed by large-scale molecular dynamics simulation". Biochemistry. 52 (47): 8527–38. doi:10.1021/bi4010683. PMC 3927399. PMID 24224757.
Guo CJ, Atochina-Vasserman EN, Abramova E, Foley JP, Zaman A, Crouch E, et al. (November 2008). "S-nitrosylation of surfactant protein-D controls inflammatory function". PLOS Biology. 6 (11): e266. doi:10.1371/journal.pbio.0060266. PMC 2581630. PMID 19007302.
Atochina-Vasserman EN, Guo CJ, Abramova E, Golden TN, Sims M, James ML, et al. (July 2015). "Surfactant dysfunction and lung inflammation in the female mouse model of lymphangioleiomyomatosis". American Journal of Respiratory Cell and Molecular Biology. 53 (1): 96–104. doi:10.1165/rcmb.2014-0224OC. PMC 4566108. PMID 25474372.
Atochina-Vasserman EN, Winkler C, Abramova H, Schaumann F, Krug N, Gow AJ, et al. (April 2011). "Segmental allergen challenge alters multimeric structure and function of surfactant protein D in humans". American Journal of Respiratory and Critical Care Medicine. 183 (7): 856–64. doi:10.1164/rccm.201004-0654OC. PMC 3086753. PMID 21131470.

External links

Surfactant+Protein+D at the US National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133661 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021795 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Hoppe_1994-5] Hoppe HJ, Barlow PN, Reid KB (May 1994). "A parallel three stranded alpha-helical bundle at the nucleation site of collagen triple-helix formation". FEBS Letters. 344 (2–3): 191–5. doi:10.1016/0014-5793(94)00383-1. PMID 8187882.

[pmid18980812-6] Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, et al. (October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Archives of Biochemistry and Biophysics. 290 (1): 116–26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081.

[pmid13392842-7] Lu J, Willis AC, Reid KB (June 1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". The Biochemical Journal. 284. 284 (3): 795–802. doi:10.1042/bj2840795. PMC 1132609. PMID 1339284.

[entrez2-8] "Entrez Gene: SFTPD surfactant, pulmonary-associated protein D".

[pmid183559112-9] Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME (May 2008). "Surfactant protein D alters allergic lung responses in mice and human subjects". The Journal of Allergy and Clinical Immunology. 121 (5): 1140–1147.e2. doi:10.1016/j.jaci.2008.02.011. PMC 4145593. PMID 18355911.

[Crouch_1994-10] Crouch E, Persson A, Chang D, Heuser J (June 1994). "Molecular structure of pulmonary surfactant protein D (SP-D)". The Journal of Biological Chemistry. 269 (25): 17311–9. PMID 8006040.

[pmid10101009-11] Tino MJ, Wright JR (April 1999). "Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner". American Journal of Respiratory Cell and Molecular Biology. 20 (4): 759–68. doi:10.1165/ajrcmb.20.4.3439. PMID 10101009. S2CID 29437779.

[pmid9153228-12] Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C, et al. (May 1997). "Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule". The Journal of Biological Chemistry. 272 (21): 13743–9. doi:10.1074/jbc.272.21.13743. PMID 9153228.

[13] Goh BC, Rynkiewicz MJ, Cafarella TR, White MR, Hartshorn KL, Allen K, et al. (November 2013). "Molecular mechanisms of inhibition of influenza by surfactant protein D revealed by large-scale molecular dynamics simulation". Biochemistry. 52 (47): 8527–38. doi:10.1021/bi4010683. PMC 3927399. PMID 24224757.

[14] Guo CJ, Atochina-Vasserman EN, Abramova E, Foley JP, Zaman A, Crouch E, et al. (November 2008). "S-nitrosylation of surfactant protein-D controls inflammatory function". PLOS Biology. 6 (11): e266. doi:10.1371/journal.pbio.0060266. PMC 2581630. PMID 19007302.

[15] Atochina-Vasserman EN, Guo CJ, Abramova E, Golden TN, Sims M, James ML, et al. (July 2015). "Surfactant dysfunction and lung inflammation in the female mouse model of lymphangioleiomyomatosis". American Journal of Respiratory Cell and Molecular Biology. 53 (1): 96–104. doi:10.1165/rcmb.2014-0224OC. PMC 4566108. PMID 25474372.

[16] Atochina-Vasserman EN, Winkler C, Abramova H, Schaumann F, Krug N, Gow AJ, et al. (April 2011). "Segmental allergen challenge alters multimeric structure and function of surfactant protein D in humans". American Journal of Respiratory and Critical Care Medicine. 183 (7): 856–64. doi:10.1164/rccm.201004-0654OC. PMC 3086753. PMID 21131470.

Surfactant protein D

Interactions

See also

References

Further reading

External links