TNIP1

TNFAIP3-interacting protein 1 is a protein that in humans is encoded by the TNIP1 gene.[5][6][7]

TNIP1
Identifiers
AliasesTNIP1, ABIN-1, NAF1, VAN, nip40-1, TNFAIP3 interacting protein 1
External IDsOMIM: 607714 MGI: 1926194 HomoloGene: 31355 GeneCards: TNIP1
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5q33.1Start151,029,945 bp[1]
End151,093,577 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10318

57783

Ensembl

ENSG00000145901

ENSMUSG00000020400

UniProt

Q15025

Q9WUU8

RefSeq (mRNA)

NM_001199275
NM_001199276
NM_001271455
NM_001271456
NM_021327

RefSeq (protein)

NP_001186204
NP_001186205
NP_001258384
NP_001258385
NP_067302

Location (UCSC)Chr 5: 151.03 – 151.09 MbChr 11: 54.91 – 54.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Association with autoimmune diseases

Genetic variations within the region of the TNIP1 gene have been shown to have association with several autoimmune diseases:

Interactions

TNIP1 contains multiple amino acid sites that are phosphorylated and ubiquitinated,[13] and has been shown to interact with TNFAIP3,[14] MAP3K1,[15] and MAPK1.[16]

References

  1. GRCh38: Ensembl release 89: ENSG00000145901 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020400 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fukushi M, Dixon J, Kimura T, Tsurutani N, Dixon MJ, Yamamoto N (Jan 1999). "Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression". FEBS Letters. 442 (1): 83–8. doi:10.1016/S0014-5793(98)01631-7. PMID 9923610. S2CID 86298611.
  6. Gupta K, Ott D, Hope TJ, Siliciano RF, Boeke JD (Dec 2000). "A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions". Journal of Virology. 74 (24): 11811–24. doi:10.1128/JVI.74.24.11811-11824.2000. PMC 112464. PMID 11090181.
  7. "Entrez Gene: TNIP1 TNFAIP3 interacting protein 1".
  8. Allanore Y, Saad M, Dieudé P, Avouac J, Distler JH, Amouyel P, et al. (Jul 2011). "Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis". PLOS Genetics. 7 (7): e1002091. doi:10.1371/journal.pgen.1002091. PMC 3131285. PMID 21750679.
  9. Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, et al. (Feb 2009). "Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways". Nature Genetics. 41 (2): 199–204. doi:10.1038/ng.311. PMC 2745122. PMID 19169254.
  10. Bowes J, Orozco G, Flynn E, Ho P, Brier R, Marzo-Ortega H, et al. (Sep 2011). "Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis". Annals of the Rheumatic Diseases. 70 (9): 1641–4. doi:10.1136/ard.2011.150102. PMC 3147229. PMID 21623003.
  11. Gateva V, Sandling JK, Hom G, Taylor KE, Chung SA, Sun X, et al. (Nov 2009). "A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus". Nature Genetics. 41 (11): 1228–33. doi:10.1038/ng.468. PMC 2925843. PMID 19838195.
  12. Han JW, Zheng HF, Cui Y, Sun LD, Ye DQ, Hu Z, et al. (Nov 2009). "Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus". Nature Genetics. 41 (11): 1234–7. doi:10.1038/ng.472. PMID 19838193. S2CID 205356205.
  13. "TNIP1 (human)". www.phosphosite.org. Retrieved 2020-10-31.
  14. Heyninck K, De Valck D, Vanden Berghe W, Van Criekinge W, Contreras R, Fiers W, Haegeman G, Beyaert R (Jun 1999). "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN". The Journal of Cell Biology. 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. PMC 2133159. PMID 10385526.
  15. Charlaftis, Nikolaos; Suddason, Tesha; Wu, Xuefeng; Anwar, Saba; Karin, Michael; Gallagher, Ewen (2014-11-03). "The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines". The EMBO Journal. 33 (21): 2581–2596. doi:10.15252/embj.201488351. ISSN 1460-2075. PMC 4282369. PMID 25260751.
  16. Zhang S, Fukushi M, Hashimoto S, Gao C, Huang L, Fukuyo Y, Nakajima T, Amagasa T, Enomoto S, Koike K, Miura O, Yamamoto N, Tsuchida N (Sep 2002). "A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling". Biochemical and Biophysical Research Communications. 297 (1): 17–23. doi:10.1016/S0006-291X(02)02086-7. PMID 12220502.

Further reading

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